Low social rhythm regularity predicts first onset of bipolar spectrum disorders among at-risk individuals with reward hypersensitivity.
Low social rhythm regularity predicts first onset of bipolar spectrum disorders among at-risk individuals with reward hypersensitivity.
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DOI：
10.1037/abn0000107
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发表时间：
2015-11
影响因子：
4.6
通讯作者：
Abramson LY
中科院分区：
文献类型：
--
作者：
Alloy LB;Boland EM;Ng TH;Whitehouse WG;Abramson LY
社会授时因子模型表明，不规律的日常安排或社会节奏易患双相情感障碍。这项研究测试了社会节律的规律性是否能在表现出奖励超敏反应的基础上，前瞻性地预测已经有双相情感障碍风险的青少年双相情感障碍的首次终身发病。青少年（14 - 19岁）先前筛选为高（N = 138）或中度（N = 95）奖励敏感性，但没有双相情感障碍的终生病史，完成抑郁和躁狂症状的测量，双相情感障碍家族史和社会节律测量。他们每六个月进行一次半结构化的诊断性访谈，平均随访31.7个月（SD = 20.1）。分层逻辑回归显示，在控制随访时间、性别、年龄、双相情感障碍家族史以及初始躁狂和抑郁症状的情况下，基线时较低的社会节律规律性预示着高回报敏感性青少年首次发作双相情感障碍的可能性大于随访时（β=−）。150, Wald = 4.365, p = 0.037, OR = 0.861, 95% CI = 0.748 - 0.991)。与社会时间因子理论一致，低社会节律规律使高危青少年易患双相情感障碍。基于在发病前表现出奖励超敏反应和社会节律紊乱，有可能识别出有发展为双相情感障碍风险的青少年。
The social zeitgeber model suggests that irregular daily schedules or social rhythms provide vulnerability to bipolar spectrum disorders. This study tested whether social rhythm regularity prospectively predicted first lifetime onset of bipolar spectrum disorders in adolescents already at risk for bipolar disorder based on exhibiting reward hypersensitivity. Adolescents (ages 14 – 19) previously screened to have high (N = 138) or moderate (N = 95) reward sensitivity, but no lifetime history of bipolar spectrum disorder, completed measures of depressive and manic symptoms, family history of bipolar disorder, and the Social Rhythm Metric. They were followed prospectively with semi-structured diagnostic interviews every six months for an average of 31.7 (SD = 20.1) months. Hierarchical logistic regression indicated that low social rhythm regularity at baseline predicted greater likelihood of first onset of bipolar spectrum disorder over follow-up among high, but not moderate, reward sensitivity adolescents, controlling for follow-up time, gender, age, family history of bipolar disorder, and initial manic and depressive symptoms (β= −.150, Wald = 4.365, p = .037, OR = .861, 95% CI = .748 – .991). Consistent with the social zeitgeber theory, low social rhythm regularity provides vulnerability to first onset of bipolar spectrum disorder among at-risk adolescents. It may be possible to identify adolescents at risk for developing a bipolar spectrum disorder based on exhibiting both reward hypersensitivity and social rhythm irregularity before onset occurs.