Evidence that N-terminal fragments of nociceptin modulate nociceptin-induced scratching, biting and licking in mice
Evidence that N-terminal fragments of nociceptin modulate nociceptin-induced scratching, biting and licking in mice
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伤害感受肽 N 末端片段调节伤害感受肽诱导的小鼠抓、咬和舔的证据
DOI：
10.1016/s0304-3940(99)00958-1
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发表时间：
2000
影响因子：
2.5
通讯作者：
L. Terenius
中科院分区：
文献类型：
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作者：
T. Sakurada;S. Sakurada;S. Katsuyama;Takafumi Hayashi;C. Sakurada;K. Tan;H. Johansson;J. Sandin;L. Terenius
鞘内 (i.t.) 注射 3.0 fmol 伤害感受肽（孤啡肽 FQ）可引起小鼠抓、咬和舔反应。伤害感受肽、伤害感受肽 (1-7)、伤害感受肽 (1-9) 和伤害感受肽 (1-13) 的 N 端片段未诱导特征性行为反应。当这些伤害感受肽的 N 末端片段与伤害感受肽同时注射时，伤害感受肽诱导的行为反应呈剂量依赖性降低。伤害感受肽 (1-13) 比伤害感受肽 (1-7) 和伤害感受肽 (1-9) 更有效，并且在等摩尔剂量下可以拮抗伤害感受肽诱导的反应。没有观察到 N 端片段对 i.t. 引起的抓、咬和舔反应的显着影响。施用 P 物质或 N-甲基-d-天冬氨酸盐。这些结果表明，脊髓内源性形成的 N 末端片段可能对伤害感受素诱导的行为反应具有拮抗作用。
The intrathecal (i.t.) injection of 3.0 fmol nociceptin (orphanin FQ) elicited scratching, biting and licking responses in mice. N-terminal fragments of nociceptin, nociceptin (1–7), nociceptin (1–9) and nociceptin (1–13), induced no characteristic behavioral response. When these N-terminal fragments of nociceptin were injected simultaneously with nociceptin, the behavioral response induced by nociceptin was reduced dose-dependently. Nociceptin (1–13) was much more potent than nociceptin (1–7) and nociceptin (1–9) and antagonized nociceptin-induced response at equimolar doses. No significant effects of the N-terminal fragments were observed against the scratching, biting and licking response elicited by i.t. administration of substance P or N-methyl-d-aspartate. These results suggest that N-terminal fragments formed endogenously in the spinal cord may have an antagonistic effect on nociceptin-induced behavioral responses.
DOI：
--
发表时间：
1997-08
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
G. Rossi;L. Leventhal;E. Bolan;G. Pasternak
通讯作者：
G. Rossi;L. Leventhal;E. Bolan;G. Pasternak
DOI：
10.1006/bbrc.1996.5867
发表时间：
1997-01-13
影响因子：
3.1
作者：
Mathis, JP;RyanMoro, J;Pasternak, GW
通讯作者：
Pasternak, GW