Medium ring ethers by ring expansion-ring contraction: Synthesis of lauthisan
Medium ring ethers by ring expansion-ring contraction: Synthesis of lauthisan
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DOI：
10.1021/ol0262946
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发表时间：
2002-09-05
期刊：
影响因子：
5.2
通讯作者：
De Voss, JJ
中科院分区：
文献类型：
--
作者：
Coster, MJ;De Voss, JJ
[图形]一种新的中环醚的一般性的建设方法已经开发出来。这涉及卤代-O，S-缩醛的扩环，然后是Ramburg-Backlund缩环反应，伴随着硫原子的挤出。该方法已用于顺式和反式劳他生的合成。
[GRAPHICS]A new general method for the construction of medium ring ethers has been developed. This involves the ring expansion of halo-O,S-acetals followed by a Ramburg-Backlund ring contraction reaction with concomitant extrusion of the sulfur atom. This methodology has been utilized for the synthesis of cis- and trans-lauthisan.