Can we improve the clinical risk score? The prognostic value of p53, Ki-67 and thymidylate synthase in patients undergoing radical resection of colorectal liver metastases
Can we improve the clinical risk score? The prognostic value of p53, Ki-67 and thymidylate synthase in patients undergoing radical resection of colorectal liver metastases
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DOI：
10.1111/hpb.12089
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发表时间：
2014-03-01
期刊：
影响因子：
2.9
通讯作者：
Potrc, Stojan
中科院分区：
文献类型：
--
作者：
Ivanecz, Arpad;Kavalar, Rajko;Potrc, Stojan
ObjectivesThe的目的是评估生物标志物是否可以提供额外的临床风险评分（CRS）提供的结直肠癌肝转移patients with colorectal liver metastasis.MethodsA回顾性审查的前瞻性维护的数据库进行了预后信息。本研究选择的患者在1996年至2011年期间接受了潜在治愈性肝脏手术治疗。p53，Ki-67和胸苷酸合成酶的表达进行了测定，使用免疫组织化学技术组织microarrais.ResultsA共98（24%）的406例患者符合纳入标准。中位随访时间为103个月。分析显示p53蛋白过表达与高CRS之间存在相关性（P = 0.058）。多变量分析后，只有高CRS仍然是生存率的独立阴性预后预测因子（P = 0.018），以及疾病早期复发的指标（P = 0.010）。在所研究的生物学标志物中，只有Ki-67过表达被确定为多变量分析的生存率的阳性预测因子（P = 0.038）。只有高CRS仍然是一个独立的负面预后预测因素。
ObjectivesThe aim of this study was to assess whether biological markers can provide prognostic information additional to that supplied by the clinical risk score (CRS) in patients with colorectal liver metastases.MethodsA retrospective review of a prospectively maintained database was conducted. Patients selected for this study were treated between 1996 and 2011 with potentially curative liver surgery. Expressions of p53, Ki-67 and thymidylate synthase were assayed using immunohistochemical techniques on tissue microarrays.ResultsA total of 98 (24%) of 406 patients met the inclusion criteria. The median follow-up was 103months. Analysis revealed a correlation between p53 protein overexpression and high CRS (P = 0.058). Following multivariate analysis, only high CRS remained as an independent negative prognostic predictor of survival (P = 0.018), as well as an indicator of early recurrence of disease (P = 0.010). Of the biological markers investigated, only Ki-67 overexpression was identified as a positive predictor of survival on multivariate analysis (P = 0.038).ConclusionsKi-67 overexpression was a positive predictor of survival. Only high CRS remained an independent negative prognostic predictor.