Association between Mismatch-repair Genetic variation and the Risk of Multiple Primary Cancers: A Meta-Analysis.
Association between Mismatch-repair Genetic variation and the Risk of Multiple Primary Cancers: A Meta-Analysis.
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错配修复遗传变异与多原发癌症风险之间的关联：荟萃分析
DOI：
10.7150/jca.19810
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发表时间：
2017
影响因子：
3.9
通讯作者：
Xia L
中科院分区：
文献类型：
--
作者：
Kong P;Wu R;Lan Y;He W;Yang C;Yin C;Yang Q;Jiang C;Xu D;Xia L
微卫星不稳定性（MSI）是多种原发性癌症（MPC）的危险因素。然而，各种研究集中在遗传性非息肉病性结直肠癌（HNPCC）的风险，而不是散发性结直肠癌（CRC）患者。本荟萃分析的目的是全面综述和定量总结MSI与MPC风险之间的关系。在MEDLINE、EMBASE、Web of science、ScienceDirect、Weily和奥维德中进行了全面的文献检索。截至2016年5月，我们确定了22项观察性研究。我们使用固定效应或随机效应模型计算了MSI患者与微卫星稳定性（MSS）患者发生MPC风险的汇总相对风险（RR）。错配修复基因（MMR）基因型与MPC之间关联的RR为2.59（95%置信区间[CI]，2.06至3.27）; MSI与MSS类别中散发性CRC的RR为2.14（95% CI，1.78至2.57），HNPCC的RR为5.59（95% CI，2.69至11.59）。亚组分析显示不同的突变基因、突变位点和突变水平对MPCs易感性的影响不同。此外，MSI基因型增加MPC的风险在部位、时间、年龄和检测方法方面没有明显的特异性。总之，该荟萃分析表明，MSI与HNPCC和散发性CRC患者中MPC风险增加相关。我们的研究结果将形成MSI基因型治疗的骨干，可能是预防MPC的重要有价值的策略。
Microsatellites instability (MSI) is a risk factor for multiple primary cancers (MPCs). However, a variety of studies focused on the risk in the hereditary non-polyposis colorectal cancer (HNPCC) not the sporadic colorectal cancer (CRC) patients. The aim of this meta-analysis was to comprehensive overview and quantitative summary the association between MSI and risk of MPCs. A comprehensive literature search in MEDLINE, EMBASE, Web of science, ScienceDirect, Weily and OVID was conducted. Up to May 2016, we identified 22 observational studies. We calculated the summary relative risk (RR) for the risk of MPCs in MSI patients compared with microsatellites stability (MSS) patients using fixed- or random-effects models. The RR of the association between mismatch-repair gene (MMR) genotype and MPCs was 2.59 (95% confidence interval [CI], 2.06 to 3.27); the RR was 2.14 (95% CI, 1.78 to 2.57) for sporadic CRC and 5.59 (95% CI, 2.69 to 11.59) for HNPCC for the MSI versus MSS category. The subgroup analyses showed different mutant gene, mutant locus, and mutant level of MMR with different influence on the patients susceptible to MPCs. In addition, MSI genotype increase the risk of MPC was not associated with an apparently specific in regard to site, timing, age and detection method. In conclusion, this meta-analysis indicates that MSI is associated with an increased risk of MPCs both in the HNPCC and sporadic CRC patients. Our findings will form the backbone of the treatment for MSI genotype may be an important valuable strategy for MPCs prevention.
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影响因子：
29.4
作者：
Boland CR;Goel A
通讯作者：
Goel A
MLH1，MSH2和MSH6在多种结直肠癌的发展中的作用。
影响因子：
8.8
作者：
Lawes, DA;Pearson, T;SenGupta, S;Boulos, PB
通讯作者：
Boulos, PB
影响因子：
--
作者：
Bacher JW;Flanagan LA;Smalley RL;Nassif NA;Burgart LJ;Halberg RB;Megid WM;Thibodeau SN
通讯作者：
Thibodeau SN
影响因子：
5.6
作者：
Farris, Alton B., III;Demicco, Elizabeth G.;Mino-Kenudson, Mari
通讯作者：
Mino-Kenudson, Mari
影响因子：
2.5
作者：
Kim, Shin Hyuk;Ahn, Byung Kyu;Lee, Kang Hong
通讯作者：
Lee, Kang Hong