Molecular Aspects of Lifestyle and Environmental Effects in Patients With Diabetes: JACC Focus Seminar.
Molecular Aspects of Lifestyle and Environmental Effects in Patients With Diabetes: JACC Focus Seminar.
复制标题
糖尿病患者生活方式和环境影响的分子方面：JACC 焦点研讨会。
DOI：
10.1016/j.jacc.2021.02.070
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发表时间：
2021
影响因子：
24
通讯作者：
Shah,RaviV
中科院分区：
文献类型：
--
作者：
Nayor,Matthew;Shah,SvatiH;Murthy,Venkatesh;Shah,RaviV
糖尿病的特征是多个组织代谢失调的综合病症，对心血管系统具有公认的后果。在大型人类观察性和干预性研究中，生物液体和组织中精确表型分析的最新进展为将模型和细胞系统中的开创性发现转化为糖尿病及其并发症风险患者提供了独特的机会。具体而言，检测代谢物、蛋白质和转录物的技术，以及最近对肠道微生物组的评估，强调了糖尿病患者的复杂性，提出了精确的风险表型分析、干预反应和潜在的新型疗法的途径。此外，外部因素和输入（例如，活动，饮食，药物治疗）对分子表征的每个领域的影响已经变得突出，以更好地理解其在预防中的作用。在这里，作者提供了一个广泛的概述，这些分子结构域中的几个在人类翻译研究糖尿病的作用。
Diabetes is characterized as an integrated condition of dysregulated metabolism across multiple tissues, with well-established consequences on the cardiovascular system. Recent advances in precision phenotyping in biofluids and tissues in large human observational and interventional studies have afforded a unique opportunity to translate seminal findings in models and cellular systems to patients at risk for diabetes and its complications. Specifically, techniques to assay metabolites, proteins, and transcripts, alongside more recent assessment of the gut microbiome, underscore the complexity of diabetes in patients, suggesting avenues for precision phenotyping of risk, response to intervention, and potentially novel therapies. In addition, the influence of external factors and inputs (eg, activity, diet, medical therapies) on each domain of molecular characterization has gained prominence toward better understanding their role in prevention. Here, the authors provide a broad overview of the role of several of these molecular domains in human translational investigation in diabetes.