Altered structure and functional connectivity of the central autonomic network in idiopathic rapid eye movement sleep behaviour disorder
Altered structure and functional connectivity of the central autonomic network in idiopathic rapid eye movement sleep behaviour disorder
复制标题
特发性快速动眼睡眠行为障碍中枢自主网络结构和功能连接的改变
DOI：
10.1111/jsr.13136
复制
发表时间：
2020-06-30
影响因子：
4.4
通讯作者：
Liu, Jun
中科院分区：
文献类型：
--
作者：
Li, Guanglu;Chen, Zhichun;Liu, Jun
有证据表明，外周自主神经结构可能与特发性快速眼动睡眠行为障碍(IRBD)的自主神经功能障碍有关。然而，iRBD的中枢自主神经网络(CAN)是否受到影响仍不清楚。磁共振成像数据来自65名参与者(32名iRBD患者和33名匹配的健康对照)。我们使用基于体素的形态测量和静息状态功能连通性分析相结合的方法研究了iRBD患者的CAN，并表征了CAN的变化和自主神经症状之间的关系。IRBD患者脑干、前扣带回和脑岛灰质体积明显小于健康对照组。功能连接性分析显示iRBD患者脑干与小脑后叶、颞叶和前扣带回之间的功能连接性降低。在iRBD患者中，灰质体积减少和CAN功能连接性降低都与帕金森病自主神经评分的结果量表呈负相关。本研究表明iRBD患者CaN的结构和功能连接性均存在异常。此外，相关分析表明，CaN异常也可能在iRBD自主神经症状的发生中起作用。
Evidence suggests peripheral autonomic structures may contribute to autonomic dysfunction in idiopathic rapid eye movement sleep behaviour disorder (iRBD). However, whether the central autonomic network (CAN) is affected in iRBD remains unclear. Magnetic resonance imaging data were acquired from 65 participants (32 patients with iRBD and 33 matched healthy controls). We investigated the CAN in patients with iRBD using a combined voxel-based morphometry and resting-state functional connectivity analysis and characterised the relationships between alterations of the CAN and autonomic symptoms. Patients with iRBD had significantly reduced grey matter volume in the brainstem, anterior cingulate and insula compared with healthy controls. Functional connectivity analysis revealed reduced functional connectivity between the brainstem and the cerebellum posterior lobe, temporal lobe and anterior cingulate in patients with iRBD. In patients with iRBD, both reduced grey matter volume and decreased functional connectivity of the CAN were negatively correlated with the Scales for Outcomes in Parkinson's Disease-Autonomic scores. The present study demonstrated that both the structure and the functional connectivity of the CAN were abnormal in patients with iRBD. In addition, correlation analysis suggested that CAN abnormalities may also play a role in the development of autonomic symptoms in iRBD.