In vivo evaporation rate of benzyl alcohol from human skin.
In vivo evaporation rate of benzyl alcohol from human skin.
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人皮肤体内苯甲醇的蒸发率。
DOI：
10.1002/jps.10561
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发表时间：
2004
影响因子：
3.8
通讯作者：
Kasting,GeraldB
中科院分区：
文献类型：
--
作者：
Saiyasombati,Penpan;Kasting,GeraldB
人体前臂掌侧受控条件下苯甲醇在活体条件下的蒸发速率与早期的体外研究中看到的类似于空气流量和时间的依赖关系。在与该仪器相关的初始时滞之后，剂量后2小时内的蒸发速率可以满意地用单一指数衰减来描述，速率常数与皮肤上的空气流量成正比，ν。2 h后累积蒸发剂量百分比在ν = 20mLmin−1时为16%，在ν = 100mLmin−1时为52%。活体数据分析测定的吸收速率常数与体外测定的结果相当，而蒸发速率常数与顶空体积的倒数成反比。后者的发现表明，一个简单的层流模型可以令人满意地描述两个系统在所用气流范围内的蒸发。©2004 Wiley-Liss，Inc.和美国药剂师协会药学杂志93：515-520,2004
The evaporation rate of benzyl alcohol from the human volar forearm under controlled conditionsin vivoshows a similar dependence on airflow and time to that seen in earlierin vitrostudies. After an initial time lag associated with the apparatus, evaporation rate over a 2‐h time period post‐dose was satisfactorily described by a single exponential decay with a rate constant proportional to airflow over the skin, ν. The cumulative percentage of dose evaporated after 2 h ranged from 16% at ν = 20 mL min−1to 52% at ν = 100 mL min−1. The absorption rate constant determined by an analysis of thein vivodata was equivalent to that determinedin vitro, whereas the evaporation rate constants were related by the inverse ratio of the headspace volumes. The latter finding suggests that a simple laminar flow model can satisfactorily describe evaporation in both systems over the range of airflows used. © 2004 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 93:515–520, 2004