trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.
trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.
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发表时间：
1993-06
期刊：
影响因子：
4.6
通讯作者：
L. Tessarollo;P. Tsoulfas;D. Martín-Zanca;D. Gilbert;N. Jenkins;N. Copeland;L. Parada
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文献类型：
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作者：
L. Tessarollo;P. Tsoulfas;D. Martín-Zanca;D. Gilbert;N. Jenkins;N. Copeland;L. Parada
酪氨酸激酶的Trk家族编码神经生长因子相关神经营养因子的受体。在这里，我们提出了一个发育的表达研究trkC，它编码的神经营养因子-3（NT-3）的受体。与相关基因trk和trkB一样，trkC主要在神经谱系中表达，尽管模式很复杂并且包括非神经元细胞。与trk和trkB发育表达模式的直接比较允许以下观察。(1)trkC在其他Trk基因沉默的新神经组织中表达。(2)一些组织似乎在胚胎和成人中共表达trkB和trkC受体。(3)在原肠形成胚胎中可以检测到trkC表达。这些数据提供了深入了解Trk家族受体和神经生长因子相关的神经营养因子在发育过程中的作用，并表明，除了调节神经元的存活和分化，神经营养因子/Trk受体系统可能具有更广泛的生理作用。最后，种间小鼠回交已被用来映射的位置，每个Trk基因的小鼠染色体上。与现有染色体图谱的比对确定了Trk基因与已知神经突变之间的可能联系。
The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related neurotrophins. Here we present a developmental expression study of trkC, which encodes a receptor for neurotrophin-3 (NT-3). Like the related genes, trk and trkB, trkC is expressed primarily in neural lineages although the pattern is complex and includes non-neuronal cells. Direct comparison with trk and trkB developmental expression patterns permits the following observations. (1) trkC is expressed in novel neural tissues where other Trk genes are silent. (2) Some tissues appear to coexpress trkB and trkC receptors in the embryo and in the adult. (3) trkC expression can be detected in the gastrulating embryo. These data provide insights into the role of Trk-family receptors and nerve growth factor-related neurotrophins during development and suggest that, in addition to regulating neuronal survival and differentiation, the neurotrophin/Trk receptor system may have broader physiological effects. Finally, interspecific mouse backcrosses have been used to map the location of each of the Trk genes on mouse chromosomes. Alignment with available chromosomal maps identify possible linkage between the Trk genes and known neurological mutations.