Direct asymmetric catalytic 1,2-addition of RZnX to aldehydes promoted by AlMe3 and reversal of expected stereochemistry.
Direct asymmetric catalytic 1,2-addition of RZnX to aldehydes promoted by AlMe3 and reversal of expected stereochemistry.
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DOI：
10.1039/b710681e
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发表时间：
2007-09
影响因子：
4.9
通讯作者：
Jonathan Shannon;David Bernier;D. Rawson;S. Woodward
中科院分区：
文献类型：
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作者：
Jonathan Shannon;David Bernier;D. Rawson;S. Woodward
将AlMe 3添加到RZnX（R =芳基、官能化芳基、乙烯基; X = Br、I）的市售THF溶液中同时促进Schlenk平衡（导致胜任亲核试剂）和Al-Zn-配体催化剂的形成，该Al-Zn-配体催化剂对于由醛形成Ar（1）CH（OH）Ar（2）提供80- 90%ee。
Addition of AlMe3 to commercial THF solutions of RZnX (R = aryl, functionalised aryl, vinyl; X = Br, I) simultaneously promotes Schlenk equilibria (leading to competent nucleophiles) and the formation of an Al-Zn-ligand catalyst delivering 80-90% ee for Ar(1)CH(OH)Ar(2) formation from aldehydes.