Essential updates 2018/2019: Current topics in the surgical treatment of pancreatic ductal adenocarcinoma.
Essential updates 2018/2019: Current topics in the surgical treatment of pancreatic ductal adenocarcinoma.
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DOI：
10.1002/ags3.12379
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发表时间：
2021-01
影响因子：
2.7
通讯作者：
Wakiya T
中科院分区：
文献类型：
--
作者：
Ishido K;Hakamada K;Kimura N;Miura T;Wakiya T
胰腺导管腺癌（PDAC）是高度恶性的。虽然其他器官的癌症在5年生存率方面有明显改善，但胰腺癌的5年生存率约为10%。早期复发和转移并不罕见，即使在胰腺完全手术切除后也难以获得可接受的预后。已经对各种治疗方法进行了研究，以改善PDAC的预后，包括非手术治疗在内的多学科方法已导致逐步改善。在目前的文献综述中，我们已经描述了解剖学和生物学可切除性标准的意义，R0切除术在外科治疗中的概念，微创手术的可行性，围手术期化疗的显着发展，转换手术对不可切除的PDAC的有效性，以及PDAC治疗中持续的挑战。我们还通过关注最近的趋势和主题来提供有关这些主题的重要更新。在目前的文献综述中，我们已经描述了解剖学和生物学可切除性标准的意义，R0切除术在外科治疗中的概念，微创手术的可行性，围手术期化疗的显着发展，不可切除的胰腺癌的转换手术的有效性，以及胰腺癌治疗的持续挑战。我们还通过关注最近的趋势和主题来提供有关这些主题的重要更新。
Pancreatic ductal adenocarcinoma (PDAC) is highly malignant. While cancers in other organs have shown clear improvements in 5‐year survival, the 5‐year survival rate of pancreatic cancer is approximately 10%. Early relapse and metastasis are not uncommon, making it difficult to achieve an acceptable prognosis even after complete surgical resection of the pancreas. Studies have been performed on various treatments to improve the prognosis of PDAC, and multidisciplinary approaches including non‐surgical treatments have led to gradual improvement. In the present literature review, we have described the significance of anatomical and biological resectability criteria, the concept of R0 resection in surgical treatment, the feasibility of minimally invasive surgery, the remarkable development of perioperative chemotherapy, the effectiveness of conversion surgery for unresectable PDAC, and ongoing challenges in PDAC treatment. We also provide an essential update on these subjects by focusing on recent trends and topics. In the present literature review, we have described the significance of anatomical and biological resectability criteria, the concept of R0 resection in surgical treatment, the feasibility of minimally invasive surgery, the remarkable development of perioperative chemotherapy, the effectiveness of conversion surgery for unresectable pancreatic cancer, and ongoing challenges in pancreatic cancer treatment. We also provide an essential update on these subjects by focusing on recent trends and topics.
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影响因子：
3.2
作者：
Ariake, Kyohei;Motoi, Fuyuhiko;Unno, Michiaki
通讯作者：
Unno, Michiaki
DOI：
10.1007/s00464-020-07564-x
发表时间：
2020-04-23
影响因子：
3.1
作者：
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影响因子：
3.9
作者：
Cloyd, Jordan M.;Heh, Victor;Santry, Heena
通讯作者：
Santry, Heena