LOW-INTENSITY RUNNING EXERCISE ENHANCES THE CAPILLARY VOLUME AND PRO-ANGIOGENIC FACTORS IN THE SOLEUS MUSCLE OF TYPE 2 DIABETIC RATS
LOW-INTENSITY RUNNING EXERCISE ENHANCES THE CAPILLARY VOLUME AND PRO-ANGIOGENIC FACTORS IN THE SOLEUS MUSCLE OF TYPE 2 DIABETIC RATS
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DOI：
10.1002/mus.24316
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发表时间：
2015-03-01
期刊：
影响因子：
3.4
通讯作者：
Roy, Roland R.
中科院分区：
文献类型：
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作者：
Kondo, Hiroyo;Fujino, Hidemi;Roy, Roland R.
简介：我们确定了低强度运动对Goto-Kakizaki（GK）糖尿病大鼠比目鱼肌三维毛细血管结构和相关血管生成因子的影响。研究方法：研究了四组雄性大鼠：安静的非糖尿病（Con），运动的非糖尿病对照（Ex），安静的GK，和运动的GK（GK+Ex）。Ex组和GK+Ex组大鼠在跑步机上进行慢性低强度跑步（15 m/min，60 min/次，5次/周，持续3周）。结果如下：虽然平均毛细血管体积和直径较低的GK与所有其他组相比，低强度的运动增加GK大鼠这两个措施。线粒体标记物，即，GK+Ex组SDH活性、PGC-1表达及血管生成因子水平均高于其他各组。在GK大鼠中，运动增加了血管内皮生长因子（VEGF）蛋白水平和VEGF与TSP-1的比率，这是血管生成的指标。结论：结合，结果表明，低强度运动减少了2型糖尿病肌肉的一些微循环并发症。肌肉神经51：391-399，2015
Introduction: We determined the effects of low-intensity exercise on the three-dimensional capillary structure and associated angiogenic factors in the soleus muscle of Goto-Kakizaki (GK) diabetic rats. Methods: Four groups of male rats were studied: sedentary nondiabetic (Con), exercised nondiabetic control (Ex), sedentary GK, and exercised GK (GK+Ex). Rats in the Ex and GK+Ex groups were subjected to chronic low-intensity running on a treadmill (15 m/min, 60 min/session, 5 sessions/week for 3 weeks). Results: Although mean capillary volume and diameter were lower in the GK compared with all other groups, low-intensity exercise increased both of these measures in GK rats. Mitochondrial markers, i.e., SDH activity and PGC-1 expression, and the levels of angiogenic factors were higher in the GK+Ex than all other groups. Exercise increased vascular endothelial growth factor (VEGF) protein levels and the VEGF-to-TSP-1 ratio, an indicator of angiogenesis, in GK rats. Conclusions: Combined, the results indicate that low-intensity exercise reduces some of the microcirculatory complications in type 2 diabetic muscles. Muscle Nerve 51: 391-399, 2015