Prognostic Significance of Vascular Endothelial Growth Factor-C Expression and Lymphatic Vessel Density in Supraglottic Squamous Cell Carcinoma
Prognostic Significance of Vascular Endothelial Growth Factor-C Expression and Lymphatic Vessel Density in Supraglottic Squamous Cell Carcinoma
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DOI：
10.1002/lary.20483
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发表时间：
2009-07-01
期刊：
影响因子：
2.6
通讯作者：
Chae, Yang-Seok
中科院分区：
文献类型：
--
作者：
Baek, Seung-Kuk;Jung, Kwang-Yoon;Chae, Yang-Seok
目的/假设：声门上型喉癌的常见表现为区域淋巴结转移。淋巴转移的机制尚不清楚，因为目前还没有明确区分淋巴管和血管的特异性标志物。本研究的目的是确定血管内皮生长因子-C(VEGF-C)表达和淋巴管密度(LVD)在声门上型喉癌中的预后意义。研究设计：对一组未选择的有治疗意向的声门上型喉癌患者进行回顾性研究。取石蜡包埋组织，用血管内皮生长因子-C、D2-40和CD31单抗进行免疫组织化学染色。结果：声门上型喉癌组织中VEGF-C和LVD在有无淋巴结转移和局部复发的情况下差异有统计学意义(P
Objectives/Hypothesis: Regional lymph node metastases are very common findings of supraglottic cancer. The mechanism of lymphatic metastasis is as yet unknown because there have been no specific markers that could definitely distinguish lymphatic vessels from blood vessels. The aim of this study is to identify the prognostic significance of vascular endothelial growth factor-C (VEGF-C) expression and lymphatic vessel density (LVD) in supraglottic cancer.Study Design: The prognostic value of the VEGF-C and LVD was retrospectively evaluated in an unselected series of patients treated with curative intent for supraglottic cancer.Methods: We investigated lymphatic vessels in 43 subjects who had previously been diagnosed with supraglottic cancer. Immunohistochemical staining was performed with VEGF-C, D2-40, and CD31 monoclonal antibodies on the paraffin-embedded tissues obtained from these patients. The association among the semiquantitative score of VEGF-C stained cancer cells, the density of immunohistochemically stained microvessels, and the prognostic factors of supraglottic cancers were investigated to evaluate the prognostic significance.Results: VEGF-C and LVD showed a statistically significant difference according to the presence of lymph node metastasis and regional recurrence (P