Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses.
Conventional CD4(+) T cells present bacterial antigens to induce cytotoxic and memory CD8(+) T cell responses.
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DOI：
10.1038/s41467-017-01661-7
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发表时间：
2017-11-17
影响因子：
16.6
通讯作者：
Veiga E
中科院分区：
文献类型：
--
作者：
Cruz-Adalia A;Ramirez-Santiago G;Osuna-Pérez J;Torres-Torresano M;Zorita V;Martínez-Riaño A;Boccasavia V;Borroto A;Martínez Del Hoyo G;González-Granado JM;Alarcón B;Sánchez-Madrid F;Veiga E
细菌吞噬作用和抗原交叉呈递以活化CD 8 + T细胞是专职抗原呈递细胞的主要功能。然而，传统的CD 4 + T细胞也在称为转噬作用（也称为转感染）的过程中从受感染的树突细胞中捕获和杀死细菌。在这里，我们表明，transhagocytic T细胞提出细菌抗原幼稚的CD 8 + T细胞，增殖，并成为细胞毒性的反应。CD 4 + T细胞介导的抗原呈递也在感染过程中在体内发生，并诱导具有低PD-1表达的中枢记忆CD 8 + T细胞的产生。此外，经吞噬的CD 4 + T细胞通过引发CD 8 + T细胞诱导保护性抗肿瘤免疫应答，突出了CD 4 + T细胞作为癌症免疫治疗工具的潜力。抗原呈递通常被认为是先天免疫细胞的领域，但CD 4 + T细胞可以从受感染的树突状细胞中转运细菌。在这里，作者表明CD 4 + T细胞可以穿隧细菌和肿瘤抗原，并将其呈递给CD 8 + T细胞以激活记忆和细胞毒性功能。
Bacterial phagocytosis and antigen cross-presentation to activate CD8+ T cells are principal functions of professional antigen presenting cells. However, conventional CD4+ T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8+ T cells, which proliferate and become cytotoxic in response. CD4+ T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8+ T cells with low PD-1 expression. Moreover, transphagocytic CD4+ T cells induce protective anti-tumour immune responses by priming CD8+ T cells, highlighting the potential of CD4+ T cells as a tool for cancer immunotherapy. Antigen presentation is generally considered the domain of innate immune cells, but CD4+ T cells can transphagocytose bacteria from infected dendritic cells. Here the authors show CD4+ T cells can transphagocytose bacterial and tumour antigens and present them to CD8+ T cells to activate memory and cytotoxic functions.
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影响因子：
32.4
作者：
Jung, S;Unutmaz, D;Lang, RA
通讯作者：
Lang, RA
影响因子：
10.6
作者：
D'Errico G;Machado HL;Sainz B Jr
通讯作者：
Sainz B Jr
影响因子：
6.4
作者：
Bjorkdahl, O;Barber, KA;Thomsen, LL
通讯作者：
Thomsen, LL
影响因子：
4.4
作者：
Bellone, M;Cantarella, D;Dellabona, P
通讯作者：
Dellabona, P
影响因子：
12.4
作者：
Dustin ML;Groves JT
通讯作者：
Groves JT