Hyperfractionated irradiation and concurrent cisplatin in brain stem tumors: a Pediatric Oncology Group pilot study (9139).
Hyperfractionated irradiation and concurrent cisplatin in brain stem tumors: a Pediatric Oncology Group pilot study (9139).
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脑干肿瘤中的超分割照射和同步顺铂：一项儿科肿瘤学小组试点研究 (9139)。
DOI：
10.1159/000120794
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发表时间：
1994
影响因子：
0.7
通讯作者：
Friedman,HS
中科院分区：
文献类型：
--
作者：
Kadota,RP;Mandell,LR;Fontanesi,J;Kovnar,EH;Krischer,J;Kun,LE;Friedman,HS
进行了一项I期儿科肿瘤组研究，联合7，020 cGy超分割照射（117 cGy，每日两次，间隔6小时）和增加顺铂的同时剂量，目的是对新诊断的脑干肿瘤儿童进行放射增敏治疗。在6周的放疗过程中，顺铂在第1、3和5周输注超过120小时。研究了以下顺铂剂量水平：（1）50 mg/m2/ 120 h，（2）75 mg/m2/120 h和（3）100 mg/m2/120 h。17名儿童中有16名完成了治疗。一名儿童在治疗2天后死亡，继发于肿瘤内大出血。在顺铂剂量水平3（100 mg/m2/ 120 h）下，5例可评价患者中有3例发生2-4级骨髓抑制。除此之外，未观察到其他过度毒性，包括肾毒性和耳毒性。
A phase I Pediatric Oncology Group Study was performed combining 7,020 cGy hyperfractionated irradiation (117 cGy twice daily separated by 6 h) with increasing concurrent doses of cisplatin given with the intent of radiosensitiza-tion as treatment for children with newly diagnosed brain stem tumors. Cisplatin was infused over 120 h on weeks 1,3, and 5 during a 6-week radiotherapy course. The following cisplatin dose levels were studied: (1) 50 mg/m2/ 120 h, (2) 75 mg/m2/120 h and (3) 100 mg/m2/120 h. Sixteen of 17 children completed therapy. One child expired after 2 days of treatment secondary to massive intratumoral hemorrhage. At cisplatin dose level 3 (100 mg/m2/ 120 h), grade 2-4 myelosuppression was encountered in 3 of 5 evaluable patients. Otherwise, no other excessive toxicities, including renal and ototox-icity, were noted.