A dedicated spectrometer for dissolution DNP NMR spectroscopy
A dedicated spectrometer for dissolution DNP NMR spectroscopy
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DOI：
10.1039/c002566f
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发表时间：
2010-01-01
影响因子：
3.3
通讯作者：
Koeckenberger, Walter
中科院分区：
文献类型：
--
作者：
Leggett, James;Hunter, Robert;Koeckenberger, Walter
使用低温动态核极化（DNP）结合溶解使得可以产生用于核磁共振光谱的液态应用的高度极化的核自旋系统。然而，在其当前的实施方式中，这需要在两个不同的磁体之间转移溶质，超极化策略限于具有相对长的纵向弛豫时间常数的自旋系统。在这里，我们描述了一个专用的光谱仪DNP应用程序的设计和建设，是基于一个磁铁与两个等中心。在3.35 T的低温环境中在该磁体的上室中进行DNP增强，而下室中的9.4 T等中心用于高分辨率NMR光谱。两个等中心的紧密接近（85 cm）使得可以转移处于固态的样品，而自旋极化的损失非常小。在第一次性能测试中，这种新的实验装置被证明上级涉及两个单独磁体的策略。
Using low temperature dynamic nuclear polarisation (DNP) in conjunction with dissolution makes it possible to generate highly polarised nuclear spin systems for liquid state applications of nuclear magnetic resonance spectroscopy. However, in its current implementation, which requires the transfer of the solute between two different magnets, the hyperpolarisation strategy is limited to spin systems with relatively long longitudinal relaxation time constants. Here we describe the design and construction of a dedicated spectrometer for DNP applications that is based on a magnet with two isocentres. DNP enhancement is carried out in the upper compartment of this magnet in a low temperature environment at 3.35 T, while a 9.4 T isocentre in the lower compartment is used for high resolution NMR spectroscopy. The close proximity (85 cm) of the two isocentres makes it possible to transfer the sample in the solid state with very little loss of spin polarisation. In first performance tests this novel experimental set-up proved to be superior to the strategy involving two separate magnets.