Structural Studies of Enantiomers, Racemates, and Quasiracemates: N-(4-Methylbenzoyl)methylbenzylamine and N-(4-Nitrobenzoyl)methylbenzylamine
Structural Studies of Enantiomers, Racemates, and Quasiracemates: N-(4-Methylbenzoyl)methylbenzylamine and N-(4-Nitrobenzoyl)methylbenzylamine
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对映体、外消旋体和准外消旋体的结构研究：N-(4-甲基苯甲酰基)甲基苄胺和 N-(4-硝基苯甲酰基)甲基苄胺
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
K. Wheeler
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作者：
M. Hendi;Paul Hooter;Raymond E. Davis;V. Lynch;K. Wheeler
将等量的(R)-N-(4-甲基苯甲酰基)-α-甲基苄胺和(S)-N-(4-硝基苯甲酰基)-α-甲基苄胺共结晶，得到双分子晶体，表现出准外消旋行为。这种准外消旋化合物是通过对“真正的”外消旋体的一种成分进行轻微的化学修饰而得到的，它扩展了目前关于构建准外消旋分子阵列的结构特征的知识库。对准外消旋体及其对映体组分和外消旋对映体总共五种结构进行了结晶学比较，证明了分子形状对晶体结构自组装的重要性。对准外消旋体结构的检查显示，局部分子堆积紧密模拟外消旋体的中心对称排列。然而，与我们以前对准外消旋现象的研究不同，目前的一组对映体、外消旋和准外消旋化合物缺乏任何显著的长程等结构相关性，如在...
Cocrystallization of equal portions of (R)-N-(4-methylbenzoyl)-α-methylbenzylamine and (S)-N-(4-nitrobenzoyl)-α-methylbenzylamine yields bimolecular crystals that exhibit quasiracemic behavior. Derived from a slight chemical modification of one component of the “true” racemate, this quasiracemate compound extends the current knowledge base of structural features responsible for the construction of quasiracemic molecular arrays. A crystallographic comparison of the quasiracemate structure with its enantiomeric components and racemic counterpartsa total of five structuresdemonstrates the importance of molecular shape to the self-assembly of crystalline architectures. Inspection of the quasiracemate structure reveals local molecular packing that closely mimics the centrosymmetric alignment of the racemates. Unlike our prior investigations of the quasiracemate phenomena, however, the current set of enantiomeric, racemic, and quasiracemic compounds lacks any prominent long-range isostructural correlation as in...