Neuronal nicotinic receptors, important new players in brain function
Neuronal nicotinic receptors, important new players in brain function
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DOI：
10.1016/s0014-2999(00)00066-2
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发表时间：
2000-03-30
影响因子：
5
通讯作者：
Gotti, C
中科院分区：
文献类型：
--
作者：
Clementi, F;Fornasari, D;Gotti, C
乙酰胆碱受体是阳离子通道，其开放由乙酰胆碱控制。它们是中枢和外周神经系统许多区域中的胆碱能烟碱传递的关键分子。由于形成这些受体的众多亚基所赋予的结构复杂性，它们具有不同的药理学和生物物理学性质。在这里，我们给出了一个简短的说明，已知的和统一的数据，关于神经元烟碱受体，作为介绍的文章报道，在这个问题上，为了让读者谁不熟悉的领域，把详细的信息在正确的上下文中。(C)2000 Elsevier Science B.V.保留所有权利。
Acetylcholine receptors are cationic channels whose opening is controlled by acetylcholine. They are key molecules in the colinergic nicotinic transmission in a number of areas of the central and perypheral nervous system. Because of the structural complexity, given by the numerous subunits that forms these receptors, they have different pharmacological and biophysical properties. Here we give a brief account of the known and consolidated data regarding neuronal nicotinic receptors, as as an introduction to the articles reported in this issue, in order to allow readers who are not familiar with the field to place the detailed information in the right context. (C) 2000 Elsevier Science B.V. All rights reserved.