Effects of varying the fat content of a choline-devoid diet on promotion of the emergence of gamma-glutamyl-transpeptidase positive foci in the liver carcinogen-treated rats.
Effects of varying the fat content of a choline-devoid diet on promotion of the emergence of gamma-glutamyl-transpeptidase positive foci in the liver carcinogen-treated rats.
复制标题
改变无胆碱饮食的脂肪含量对促进肝癌治疗大鼠中γ-谷氨酰转肽酶阳性病灶出现的影响。
DOI：
10.1016/0304-3835(82)90089-1
复制
发表时间：
1982
期刊：
影响因子：
9.7
通讯作者：
Abanobi,SE
中科院分区：
文献类型：
--
作者：
Shinozuka,H;Takahashi,S;Lombardi,B;Abanobi,SE
先前的研究表明，给大鼠喂食无胆碱（CD）饮食是肝癌发生的有效促进剂。在本研究中，我们研究了含有不同脂肪水平（高，15%;低，4%）的CD饲料对单剂量二乙基亚硝胺诱导的大鼠肝脏中γ-谷氨酰转肽酶（GGT）阳性肝细胞灶的诱导作用。在喂食高脂CD饲料4-6周的大鼠中，诱导的病灶数量大于喂食同样低脂CD饲料的大鼠。然而，肝脏DNA合成和肝细胞有丝分裂的速度没有显着差异，大鼠喂养的2 CD饮食，但显着高于大鼠喂养的胆碱补充饮食。这些结果表明，除了刺激肝细胞增殖外，其他因素决定了CD饮食发挥其促进作用的功效。
Previous studies have shown that feeding a choline-devoid (CD) diet to rats is an effective promoter of liver carcinogenesis. In the present studies, we investigated the effects of CD diets containing different levels of fat (high, 15%; low, 4%) on the induction of foci of γ-glutamyltranspeptidase (GGT) positive hepatocytes in the liver of rats initiated with a single dose of diethylnitrosamine. In rats fed the high-fat CD diet for 4–6 weeks, a greater number of foci was induced than in rats fed similarly the low-fat CD diet. However, liver DNA synthesis and the rate of hepatocyte mitosis were not significantly different in rats fed the 2 CD diets, but were significantly higher than in rats fed a choline-supplemented diet. These results indicate that beside stimulation of liver cell proliferation, other factor(s) determine the efficacy with which a CD diet exerts its promoting action.