Distinct Contributions of Mesencephalic Locomotor Region Nuclei to Locomotor Control in the Freely Behaving Mouse
Distinct Contributions of Mesencephalic Locomotor Region Nuclei to Locomotor Control in the Freely Behaving Mouse
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DOI：
10.1016/j.cub.2018.02.007
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发表时间：
2018-03-19
期刊：
影响因子：
9.2
通讯作者：
Bretzner, Frederic
中科院分区：
文献类型：
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作者：
Josset, Nicolas;Roussel, Marie;Bretzner, Frederic
中脑运动区（MLR）最初被确定为能够启动和调节运动的脊髓上中心。虽然它对运动的功能性贡献已经在从七鳃鳗到人类的整个进化史中得到了广泛的记载，但关于它的确切组织仍然存在争议。结合小鼠遗传学中的运动学和电生理学记录，我们的研究表明，楔状核的胆碱能神经元启动运动并诱导跑步步态，而脚桥核的胆碱能和胆碱能神经元调节运动模式和节奏，有助于缓慢行走步态。通过启动，调节和加速运动，我们的研究确定和表征这个功能区域的运动命令重要的不同的神经元群体。
The mesencephalic locomotor region (MLR) has been initially identified as a supraspinal center capable of initiating and modulating locomotion. Whereas its functional contribution to locomotion has been widely documented throughout the phylogeny from the lamprey to humans, there is still debate about its exact organization. Combining kinematic and electrophysiological recordings in mouse genetics, our study reveals that glutamatergic neurons of the cuneiform nucleus initiate locomotion and induce running gaits, whereas glutamatergic and cholinergic neurons of the pedunculopontine nucleus modulate locomotor pattern and rhythm, contributing to slow-walking gaits. By initiating, modulating, and accelerating locomotion, our study identifies and characterizes distinct neuronal populations of this functional region important to locomotor command.