Oxygen-Based Nanocarriers to Modulate Tumor Hypoxia for Ameliorated Anti-Tumor Therapy: Fabrications, Properties, and Future Directions.
Oxygen-Based Nanocarriers to Modulate Tumor Hypoxia for Ameliorated Anti-Tumor Therapy: Fabrications, Properties, and Future Directions.
复制标题
基于氧的纳米载体调节肿瘤缺氧改善抗肿瘤治疗：制造，性能和未来的方向。
DOI：
10.3389/fmolb.2021.683519
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发表时间：
2021
影响因子：
5
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Li X;Wu Y;Zhang R;Bai W;Ye T;Wang S
近五年来，氧基纳米载体在抗肿瘤治疗中的应用受到了基础研究和临床实践的广泛关注。事实上，肿瘤缺氧，由增殖活性升高和血管功能障碍引起，是许多传统治疗方式效果不佳或无效的直接原因。不可否认，产氧NCs和载氧NCs可以增加肿瘤缺氧区域的氧浓度，并且还被证明具有降低药物外排泵（例如P-gp）表达的能力；增加肿瘤细胞的吸收；促进细胞毒性活性氧化物（ROS）的生成；并唤起系统的抗肿瘤免疫反应。然而，仍有许多挑战和限制需要进一步改进。在本文中，我们首先讨论了肿瘤缺氧的机制以及它如何严重制约临床治疗的疗效。然后系统地介绍了产氧纳米碳管和载氧纳米碳管制造的最新进展。此外，本文还详细阐述了抗缺氧纳米细胞的物理化学和表面特性的改进，以提高其对缺氧细胞的靶向能力，并特别关注最新的纳米技术。最后，提出了这些神经网络的未来发展方向，特别是临床翻译方向。因此，我们希望通过本文的综合综述，为在这一前景广阔的领域中设计出更有效的氧基纳米材料提供一些有价值的启示和建议。
Over the past five years, oxygen-based nanocarriers (NCs) to boost anti-tumor therapy attracted tremendous attention from basic research and clinical practice. Indeed, tumor hypoxia, caused by elevated proliferative activity and dysfunctional vasculature, is directly responsible for the less effectiveness or ineffective of many conventional therapeutic modalities. Undeniably, oxygen-generating NCs and oxygen-carrying NCs can increase oxygen concentration in the hypoxic area of tumors and have also been shown to have the ability to decrease the expression of drug efflux pumps (e.g., P-gp); to increase uptake by tumor cells; to facilitate the generation of cytotoxic reactive oxide species (ROS); and to evoke systematic anti-tumor immune responses. However, there are still many challenges and limitations that need to be further improved. In this review, we first discussed the mechanisms of tumor hypoxia and how it severely restricts the therapeutic efficacy of clinical treatments. Then an up-to-date account of recent progress in the fabrications of oxygen-generating NCs and oxygen-carrying NCs are systematically introduced. The improved physicochemical and surface properties of hypoxia alleviating NCs for increasing the targeting ability to hypoxic cells are also elaborated with special attention to the latest nano-technologies. Finally, the future directions of these NCs, especially towards clinical translation, are proposed. Therefore, we expect to provide some valued enlightenments and proposals in engineering more effective oxygen-based NCs in this promising field in this comprehensive overview.