Psychopathology in the adolescent and young adult offspring of a community sample of mothers and fathers with major depression
Psychopathology in the adolescent and young adult offspring of a community sample of mothers and fathers with major depression
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DOI：
10.1017/s0033291704003587
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发表时间：
2005-03-01
影响因子：
6.9
通讯作者：
Olino, TM
中科院分区：
文献类型：
--
作者：
Klein, DN;Lewinsohn, PM;Olino, TM
背景。有大量文献表明，患有重度抑郁症 (MDD) 的母亲的后代患抑郁症的风险会增加。然而，关于父亲 MDD 对后代精神病理学的影响知之甚少。我们使用父母及其青少年和年轻成年后代的大型社区样本（n = 775）来解决这个问题。通过半结构化诊断访谈对父母和后代进行独立评估。后代从青春期中期到 24 岁接受了 3 次访谈。结果。母亲 MDD 与后代 MDD 显着相关。父亲的 MDD 也与后代的 MDD 显着相关，但仅限于患有中度或以上严重抑郁发作的后代。在控制了父母双方的社会经济地位、家庭完整和非情绪障碍后，这些影响仍然存在。患有早发性 MDD 的母亲和父亲的后代以及患有复发性 MDD 的父亲的后代的 MDD 发病率尤其升高。父母和后代的MDD之间的关联程度一般在中小范围内。结论。这些结果证实了之前的研究结果，即抑郁母亲的后代患 MDD 的风险较高。此外，结果表明，父亲的 MDD 与后代患抑郁症的风险增加有关，但仅限于后代中度或以上严重程度的 MDD 发作。
Background. There is a large literature indicating that the offspring of mothers with Major Depressive Disorder (MDD) are at increased risk for depression. However, much less is known about the effects of paternal MDD on offspring psychopathology.Method. We addressed this issue using a large community sample of parents and their adolescent and young adult offspring (n = 775). Parents and offspring were independently assessed with semistructured diagnostic interviews. Offspring were interviewed three times from mid-adolescence to age 24 years.Results. Maternal MDD was significantly associated with offspring MDD. Paternal MDD was also significantly associated with MDD in offspring, but only among offspring with depressive episodes of moderate or greater severity. These effects persisted after controlling for socio-economic status, family intactness, and non-mood disorders in both parents. Rates of MDD were particularly elevated in offspring of mothers and fathers with early-onset MDD, and offspring of fathers with recurrent MDD. The magnitude of the associations between MDD in parents and offspring was generally in the small-to-medium range.Conclusions. These results confirm previous findings of elevated risk of MDD in the offspring of depressed mothers. In addition, the results suggest that MDD in fathers is associated with increased risk of depression in offspring, but that it is limited to MDD episodes in offspring of moderate or greater severity.