Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis
Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis
复制标题
DOI：
10.1038/s41467-018-03386-7
复制
发表时间：
2018-03-08
影响因子：
16.6
通讯作者：
Ghezzi, Diego
中科院分区：
文献类型：
--
作者：
Ferlauto, Laura;Leccardi, Marta Jole Ildelfonsa Airaghi;Ghezzi, Diego
视网膜假体已经被开发用于对抗受视网膜外层营养不良影响的人的失明。迄今为止，已有数百名患者接受了视网膜植入手术。受人工晶状体的启发，我们设计了一种可折叠的光伏宽视野视网膜前膜假体（名为POLYRETINA），能够刺激无线视网膜神经节细胞。在这里，我们表明，在46.3度的视角内，POLYRETINA嵌入了2215个刺激像素，其中967个位于5 mm的中心区域，它是可折叠的，允许通过小的巩膜切口植入，并且它具有半球形形状以匹配眼睛的曲率。我们证明其无细胞毒性，符合光学和热安全标准;加速老化显示其寿命至少为2年。POLYRETINA代表了使用同一器械改善视力和视野的重大进展，这是该领域目前的挑战性问题。
Retinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies. To date, few hundred patients have received a retinal implant. Inspired by intraocular lenses, we have designed a foldable and photovoltaic wide-field epiretinal prosthesis (named POLYRETINA) capable of stimulating wireless retinal ganglion cells. Here we show that within a visual angle of 46.3 degrees, POLYRETINA embeds 2215 stimulating pixels, of which 967 are in the central area of 5 mm, it is foldable to allow implantation through a small scleral incision, and it has a hemispherical shape to match the curvature of the eye. We demonstrate that it is not cytotoxic and respects optical and thermal safety standards; accelerated ageing shows a lifetime of at least 2 years. POLYRETINA represents significant progress towards the improvement of both visual acuity and visual field with the same device, a current challenging issue in the field.