The 9cis,11trans,13cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in HepG2 cells
The 9cis,11trans,13cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in HepG2 cells
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DOI：
10.1271/bbb.68.2643
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发表时间：
2004-12-01
影响因子：
1.6
通讯作者：
Yanagita, T
中科院分区：
文献类型：
--
作者：
Arao, K;Yotsumoto, H;Yanagita, T
本文研究了9 cis，11 transs，13 cis-共轭亚麻酸（9 c，11 t，13 c-CLNA）对人肝癌HepG 2细胞的生理效应。与α-亚麻酸（alpha-linolenic acid，alpha-LNA）相比，9 c，11 t，13 c-CLNA显著降低载脂蛋白13100的分泌。9 c，11 t，13 c-CLNA对C-14-油酸酯向新合成的细胞三酰甘油中的摄取的降低也大于α-LNA处理。这是第一项显示9 c，11 t，13 c-CLNA降血脂作用的研究。
The physiological effects of 9cis,11trans,13cis-conjugated linolenic acid (9c,11t,13c-CLNA), one of the CLNA isomers, were studied in human hepatoma HepG2 cells. 9c,11t,13c-CLNA significantly decreased apolipoprotein 13100 secretion compared with alpha-linolenic acid (alpha-LNA). The uptake of C-14-oleate into newly synthesized cellular triacylglycerol was also decreased by 9c,11t,13c-CLNA more than by alpha-LNA treatment. This is the first study to show the hypolipidemic effect of 9c,11t,13c-CLNA.