Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.
Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.
复制标题
作者校正：短疗法，大剂量利福平可实现沃尔巴氏菌的耗竭预测淋巴丝虫病和脑尾c的临床前模型中的治愈结果。
DOI：
10.1038/s41598-018-19723-1
复制
发表时间：
2018-01-18
影响因子：
4.6
通讯作者：
Ward SA
中科院分区：
文献类型：
--
作者：
Aljayyoussi G;Tyrer HE;Ford L;Sjoberg H;Pionnier N;Waterhouse D;Davies J;Gamble J;Metuge H;Cook DAN;Steven A;Sharma R;Guimaraes AF;Clare RH;Cassidy A;Johnston KL;Myhill L;Hayward L;Wanji S;Turner JD;Taylor MJ;Ward SA
Lymphatic filariasis (LF) and onchocerciasis are priority neglected tropical diseases targeted for elimination. The only safe drug treatment with substantial curative activity against the filarial nematodes responsible for LF (Brugia malayi, Wuchereria bancrofti) or onchocerciasis (Onchocerca volvulus) is doxycycline. The target of doxycycline is the essential endosymbiont,Wolbachia.Four to six weeks doxycycline therapy achieves >90% depletion ofWolbachiain worm tissues leading to blockade of embryogenesis, adult sterility and premature death 18–24 months post-treatment. Long treatment length and contraindications in children and pregnancy are obstacles to implementing doxycycline as a public health strategy. Here we determine, via preclinical infection models ofBrugia malayiorOnchocerca ochengithat elevated exposures of orally-administered rifampicin can lead toWolbachiadepletions from filariae more rapidly than those achieved by doxycycline. Dose escalation of rifampicin achieves >90%Wolbachiadepletion in time periods of 7 days inB. malayiand 14 days inO. ochengi. Using pharmacokinetic-pharmacodynamic modelling and mouse-human bridging analysis, we conclude that clinically relevant dose elevations of rifampicin, which have recently been determined as safe in humans, could be administered as short courses to filariasis target populations with potential to reduce anti-Wolbachiacurative therapy times to between one and two weeks.
影响因子：
4.6
作者：
Aljayyoussi G;Tyrer HE;Ford L;Sjoberg H;Pionnier N;Waterhouse D;Davies J;Gamble J;Metuge H;Cook DAN;Steven A;Sharma R;Guimaraes AF;Clare RH;Cassidy A;Johnston KL;Myhill L;Hayward L;Wanji S;Turner JD;Taylor MJ;Ward SA
通讯作者：
Ward SA