Validation of hippocampal volumes measured using a manual method and two automated methods (FreeSurfer and IBASPM) in chronic major depressive disorder
Validation of hippocampal volumes measured using a manual method and two automated methods (FreeSurfer and IBASPM) in chronic major depressive disorder
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DOI：
10.1007/s00234-008-0383-9
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发表时间：
2008-07-01
期刊：
影响因子：
2.8
通讯作者：
Kim, Keun Woo
中科院分区：
文献类型：
--
作者：
Tae, Woo Suk;Kim, Sam Soo;Kim, Keun Woo
引言
为验证可用于海马体自动体积测量的软件包的有效性，我们使用一种手动方法和两种近期开发的自动体积测量方法来测量海马体体积。
方法
该研究包括21例慢性重度抑郁症（MDD）患者和20例正常对照者的T1加权磁共振成像（MRI）。使用层厚为1.3 mm的冠状快速场回波（TFE）MRI，通过三种方法测量海马体体积：手动体积测量、使用FreeSurfer的基于表面的分割以及使用IBASPM的基于个体图谱的体积测量。此外，手动测量颅腔体积（ICV）。
结果
使用所有三种方法测量的MDD患者的左侧海马体绝对体积均显著小于正常对照者的左侧海马体体积（手动法P = 0.029，FreeSurfer法P = 0.035，IBASPM法P = 0.018）。在控制ICV后，除了使用FreeSurfer测量的右侧海马体体积外，MDD患者的两侧海马体测量体积均显著小于正常对照者的海马体测量体积（右侧手动法P = 0.019，IBASPM法P = 0.012；左侧手动法P = 0.003，FreeSurfer法P = 0.010，IBASPM法P = 0.002）。在评分者内信度检验中，组内相关系数（ICCs）均极佳（右侧手动法0.947，左侧0.934；FreeSurfer右侧1.000，左侧1.000；IBASPM右侧1.000，左侧1.000）。在体积测量方法之间的一致性检验中，ICCs为右侧0.846和左侧0.848（手动法和FreeSurfer），以及右侧0.654和左侧0.717（手动法和IBASPM）。
结论
海马体自动体积测量方法与手动海马体体积测量法具有良好的一致性，但使用FreeSurfer测量的体积大35%，且与IBASPM的一致性存疑。尽管自动方法能够检测MDD患者的海马体萎缩，但结果表明手动海马体体积测量法仍然是金标准，而自动体积测量方法需要改进。
Introduction To validate the usefulness of the packages available for automated hippocampal volumetry, we measured hippocampal volumes using one manual and two recently developed automated volumetric methods.Methods The study included T1-weighted magnetic resonance imaging (MRI) of 21 patients with chronic major depressive disorder (MDD) and 20 normal controls. Using coronal turbo field echo (TFE) MRI with a slice thickness of 1.3 mm, the hippocampal volumes were measured using three methods: manual volumetry, surface-based parcellation using FreeSurfer, and individual atlas-based volumetry using IBASPM. In addition, the intracranial cavity volume (ICV) was measured manually.Results The absolute left hippocampal volume of the patients with MDD measured using all three methods was significantly smaller than the left hippocampal volume of the normal controls (manual P=0.029, FreeSurfer P=0.035, IBASPM P=0.018). After controlling for the ICV, except for the right hippocampal volume measured using Free Surfer, both measured hippocampal volumes of the patients with MDD were significantly smaller than the measured hippocampal volumes of the normal controls (right manual P=0.019, IBASPM P=0.012; left manual P=0.003, Free Surfer P=0.010, IBASPM P=0.002),. In the intrarater reliability test, the intraclass correlation coefficients (ICCs) were all excellent (manual right 0.947, left 0.934; Free Surfer right 1.000, left 1.000; IBASPM right 1.000, left 1.000). In the test of agreement between the volumetric methods, the ICCs were right 0.846 and left 0.848 (manual and FreeSurfer), and right 0.654 and left 0.717 (manual and IBASPM).Conclusion The automated hippocampal volumetric methods showed good agreement with manual hippocampal volumetry, but the volume measured using FreeSurfer was 35% larger and the agreement was questionable with IBASPM. Although the automated methods could detect hippocampal atrophy in the patients with MDD, the results indicate that manual hippocampal volumetry is still the gold standard, while the automated volumetric methods need to be improved.