Associations between prenatal maternal exposure to per- and polyfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) and birth outcomes among pregnant women in San Francisco
Associations between prenatal maternal exposure to per- and polyfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) and birth outcomes among pregnant women in San Francisco
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DOI：
10.1186/s12940-020-00654-2
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发表时间：
2020-09-16
影响因子：
6
通讯作者：
Morello-Frosch, Rachel
中科院分区：
文献类型：
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作者：
Eick, Stephanie M.;Hom Thepaksorn, Elizabeth K.;Morello-Frosch, Rachel
背景全氟烷基物质（PFAS）和多溴联苯醚（PBDE）分别因其防水和阻燃特性而用于消费品。然而，有广泛的产前暴露和关注其对发育中的胎儿的潜在危害。在这里，我们利用来自加利福尼亚州旧金山弗朗西斯科的人口统计学上多样化的妇女队列的数据来检查产前暴露于PFAS和多溴二苯醚与胎龄和出生体重胎龄z分数之间的关联。方法纳入本分析的女性参加了我们体内的化学物质（CIOB）队列研究（N = 506）。PFAS和多溴二苯醚测量血清中获得的妊娠中期。使用线性回归模型计算三分位数中PFAS和多溴二苯醚浓度与胎龄和出生体重z分数之间关系的粗β系数和调整β系数。在不同的模型中对PFAS和多溴二苯醚的浓度及其总和进行了检测。结果：BDE-47的最高三分位数与最低三分位数相比，与较短的胎龄相关（β = -0. 49，95%置信区间[CI] = -0. 95，-0. 02）。此外，与接触量最低的三分位数相比，接触BDE-47和BDE-99的中间三分位数也与出生体重z评分降低有关（分别为β = -0. 26，95% CI =-0. 48，-0. 04; β = -0. 25，95% CI =-0. 47，-0. 04）。在PFAS浓度增加与胎龄或出生体重z评分之间未观察到一致的相关性。讨论在旧金山弗朗西斯科湾区的一组不同的孕妇中，我们发现在怀孕的第二个三个月期间产前暴露于多溴联苯醚和出生体重Z分数之间的非线性关联。然而，大多数PFAS同系物与不良出生结局无关。PFAS和PBDE浓度在我们的队列中相对于其他研究较低。未来的研究应评估新出现的和持续存在的PFAS和多溴二苯醚对出生结果的影响，因为一些同系物正在逐步淘汰，并被化学结构相似的物质所取代。
Background Perfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) are used in consumer products for their water repellent and flame retardant properties, respectively. However, there is widespread prenatal exposure and concern about their potential harm to the developing fetus. Here, we utilized data from a demographically diverse cohort of women in San Francisco, CA to examine associations between prenatal exposure to PFAS and PBDEs with gestational age and birth weight for gestational age z-scores. Methods Women included in this analysis were enrolled in the Chemicals in our Bodies (CIOB) cohort study (N = 506). PFAS and PBDEs were measured in serum obtained during the second trimester of pregnancy. Linear regression models were used to calculate crude and adjusted beta coefficients for the association between PFAS and PBDE concentrations in tertiles and gestational age and birth weight z-scores. Individual PFAS and PBDE concentrations, as well as their sums, were examined in separate models. Results The highest compared to lowest tertile of BDE-47 was associated with shorter gestational age (beta = - 0.49, 95% confidence interval [CI] = - 0.95, - 0.02). Additionally, exposure to BDE-47 and BDE-99 in the middle tertile was also associated with a reduction in birth weight z-scores (beta = - 0.26, 95% CI = -0.48, - 0.04; beta = - 0.25, 95% CI = -0.47, - 0.04, respectively) compared to those in the lowest tertile of exposure. No consistent associations were observed between increasing PFAS concentrations and gestational age or birth weight z-scores. Discussion Among a diverse group of pregnant women in the San Francisco Bay Area, we found non-linear associations between prenatal exposure to PBDEs during the second trimester of pregnancy and birth weight z-scores. However, most PFAS congeners were not associated with adverse birth outcomes. PFAS and PBDE concentrations were lower in our cohort relative to other studies. Future research should assess the effects of emerging and persistent PFAS and PBDEs on birth outcomes, as some congeners are being phased out and replaced by chemically similar structures.