Interleukin 1 beta polymorphism (-511) and risk of stroke due to small vessel disease
Interleukin 1 beta polymorphism (-511) and risk of stroke due to small vessel disease
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DOI：
10.1159/000087928
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Szczudlik, A
中科院分区：
文献类型：
--
作者：
Dziedzic, T;Slowik, A;Szczudlik, A
背景：白细胞介素1（IL-1）是一种促炎细胞因子，参与动脉粥样硬化和血栓形成。本研究旨在探讨IL-1 β基因多态性（-511）与大血管病（LVD）卒中、小血管病（SVD）卒中和心源性栓塞（CE）卒中风险之间的关系。研究方法：我们对115例LVD卒中患者和194例匹配对照、122例SVD卒中患者和227例对照以及221例CE卒中患者和219例对照进行了基因分型。通过聚合酶链反应和限制性内切酶消化分析IL-1 β多态性。结果如下：等位基因T分布在LVD卒中患者和对照组之间没有显著变化，在CE卒中患者和对照组之间也没有显著变化。SVD卒中患者的T等位基因频率高于对照组（37.7% vs. 30.4%，p = 0.05）。校正血管危险因素后，TT基因型是SVD卒中的独立危险因素（OR：2.40，95%CI：1.17 ~ 4.94）。结论：IL-1 β基因的TT基因型可能与SVD卒中的风险增加有关。版权所有（C）2005 S. Karger AG，巴塞尔。
Background: Interleukin 1 (IL-1) is a proinflammatory cytokine involved in atherogenesis and thrombosis. The aim of this study was to investigate the association between the IL-1 beta gene polymorphism ( - 511) and the risk of large vessel disease (LVD) stroke, small vessel disease (SVD) stroke and cardioembolic (CE) stroke. Methods: We genotyped 115 patients with LVD stroke and 194 matched controls, 122 patients with SVD stroke and 227 controls and 221 patients with CE stroke and 219 controls. The IL-1 beta polymorphism was analyzed by a polymerase chain reaction followed by a restriction enzyme digestion. Results: The allele T distribution did not change significantly between patients with LVD stroke and their controls nor between patients with CE stroke and their controls. The frequency of the T allele was higher in patients with SVD stroke than in the control group (37.7 vs. 30.4%, p = 0.05). After adjustment for vascular risk factor, the TT genotype was an independent risk factor for SVD stroke ( OR: 2.40, 95% CI: 1.17 - 4.94). Conclusions: The TT genotype of the IL-1 beta gene may be associated with an increased risk of SVD stroke. Copyright (C) 2005 S. Karger AG, Basel.