Longitudinal Weight Gain in Women Identified With Polycystic Ovary Syndrome: Results of an Observational Study in Young Women
Longitudinal Weight Gain in Women Identified With Polycystic Ovary Syndrome: Results of an Observational Study in Young Women
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DOI：
10.1002/oby.20213
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发表时间：
2013-08-01
期刊：
影响因子：
6.9
通讯作者：
Lombard, Catherine
中科院分区：
文献类型：
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作者：
Teede, Helena J.;Joham, Anju E.;Lombard, Catherine
目的：多囊卵巢综合症 (PCOS) 影响 6-18% 的女性。患有多囊卵巢综合症的女性体重增加的自然史尚未得到很好的描述。在这里，我们的目的是检查患有和不患有 PCOS 的女性的纵向体重增加，并评估肥胖与 PCOS 患病率之间的关联。 设计和方法：观察性研究是在普通社区进行的。参与者是从国家健康保险计划（Medicare）数据库中随机选择的女性。邮寄的调查数据由澳大利亚妇女健康纵向研究收集。对调查 4 中 28-33 岁受访者的数据进行了分析（2006 年，n = 9,145）。主要结果指标是 PCOS 患病率和体重指数 (BMI)。结果：自我报告的 PCOS 患病率为 5.8%（95% CI：5.3%-6.4%）。报告 PCOS 的女性体重、平均 BMI 较高[2.5 kg/m(2) (95% CI: 1.9-3.1)]，且 10 年体重增加较多 [2.6 kg (95% CI: 1.2-4.0)]。 BMI 与 PCOS 状态的相关性最强，BMI 每增加一次，报告 PCOS 的风险就会增加 9.2%（95% CI：6%-12%）。结论：这项以社区为基础的观察性研究对体重进行了纵向报告，结果表明，PCOS 患者的体重、BMI 和 10 年体重增加较高。我们报告了一项新发现，即肥胖和体重增加与多囊卵巢综合症显着相关。考虑到多囊卵巢综合症的患病率、主要的健康和经济负担、年轻女性体重增加以及减肥的既定益处，这些结果具有重大的公共卫生影响。
Objective: Polycystic ovary syndrome (PCOS) affects 6-18% of women. The natural history of weight gain in women with PCOS has not been well described. Here we aimed to examine longitudinal weight gain in women with and without PCOS and to assess the association between obesity and PCOS prevalence.Design and Methods: The observational study was set in the general community. Participants were women randomly selected from the national health insurance scheme (Medicare) database. Mailed survey data were collected by the Australian Longitudinal Study on Women's Health. Data from respondents to survey 4, aged 28-33 years (2006, n = 9,145) were analyzed. The main outcome measures were PCOS prevalence and body mass index (BMI).Results: Self-reported PCOS prevalence was 5.8% (95% CI: 5.3%-6.4%). Women reporting PCOS had higher weight, mean BMI [2.5 kg/m(2) (95% CI: 1.9-3.1)], and greater 10-year weight gain [2.6 kg (95% CI: 1.2-4.0)]. BMI was the strongest correlate of PCOS status with every BMI increment increasing the risk of reporting PCOS by 9.2% (95% CI: 6%-12%).Conclusions: This community based observational study with longitudinal reporting of weight shows that weight, BMI, and 10-year weight gain were higher in PCOS. We report the novel finding that obesity and greater weight gain are significantly associated with PCOS status. Considering the prevalence, major health and economic burden of PCOS, the increasing weight gain in young women, and established benefits of weight loss, these results have major public health implications.