Altered purinergic receptor expression in the frontal cortex in schizophrenia.
Altered purinergic receptor expression in the frontal cortex in schizophrenia.
复制标题
DOI：
10.1038/s41537-022-00312-1
复制
发表时间：
2022-11-14
期刊：
影响因子：
--
通讯作者：
O'Donovan, Sinead M.
中科院分区：
文献类型：
--
作者：
Alnafisah, Rawan;Lundh, Anna;Asah, Sophie M.;Hoeflinger, Julie;Wolfinger, Alyssa;Hamoud, Abdul-Rizaq;McCullumsmith, Robert E.;O'Donovan, Sinead M.
三磷酸腺苷作为神经递质作用于广泛表达的嘌呤能P2受体家族。在精神分裂症(SCZ)中，调节细胞外ATP及其对腺苷的分解代谢的途径是失调的。然而，改变的ATP可用性对SCZ患者大脑中P2受体表达的影响尚未得到评估。我们检测了诊断为精神分裂症的受试者和匹配的非精神疾病对照组(n = 20-22/组)DLPFC和Acc中P2受体基因和蛋白的表达。P2 RX7、P2 RX4和雄性P2 RX5基因表达显著增加(p <； 0.0 5)。P2 RX7蛋白亚型的表达也显著增加(p <； 0.0 5)。男性P2 RX4和P2 RX5基因表达的显著增加可能与抗精神病药物的药物作用有关。我们发现，P2RX4和P2RX7mRNA与炎症标志物SERPINA3显著相关，提示在SCZ中，P2XR表达上调可能与神经炎症有关。这些发现支持了SCZ中依赖大脑区域的嘌呤能系统的失调。
ATP functions as a neurotransmitter, acting on the ubiquitously expressed family of purinergic P2 receptors. In schizophrenia (SCZ), the pathways that modulate extracellular ATP and its catabolism to adenosine are dysregulated. However, the effects of altered ATP availability on P2 receptor expression in the brain in SCZ have not been assessed. We assayed P2 receptor mRNA and protein expression in the DLPFC and ACC in subjects diagnosed with SCZ and matched, non-psychiatrically ill controls (n = 20–22/group). P2RX7, P2RX4 and male P2RX5 mRNA expression were significantly increased (p < 0.05) in the DLPFC in SCZ. Expression of P2RX7 protein isoform was also significantly increased (p < 0.05) in the DLPFC in SCZ. Significant increases in P2RX4 and male P2RX5 mRNA expression may be associated with antipsychotic medication effects. We found that P2RX4 and P2RX7 mRNA are significantly correlated with the inflammatory marker SERPINA3, and may suggest an association between upregulated P2XR and neuroinflammation in SCZ. These findings lend support for brain-region dependent dysregulation of the purinergic system in SCZ.
登录
查看更多内容
影响因子：
12.4
作者：
Boison, D.;Chen, J-F;Fredholm, B. B.
通讯作者：
Fredholm, B. B.
影响因子：
4.8
作者：
Calovi S;Mut-Arbona P;Tod P;Iring A;Nicke A;Mato S;Vizi ES;Tønnesen J;Sperlagh B
通讯作者：
Sperlagh B
影响因子：
4.8
作者：
Feng, Ying-Hong;Li, Xin;Gorodeski, George I.
通讯作者：
Gorodeski, George I.
影响因子：
5.5
作者：
Feng, YH;Wang, LQ;Gorodeski, GI
通讯作者：
Gorodeski, GI
影响因子：
9
作者：
通讯作者：
--