Thiamin deficiency and uncomplicated falciparum malaria in Laos
Thiamin deficiency and uncomplicated falciparum malaria in Laos
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DOI：
10.1111/j.1365-3156.2006.01804.x
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发表时间：
2007-03-01
影响因子：
3.3
通讯作者：
Newton, Paul N.
中科院分区：
文献类型：
--
作者：
Mayxay, Mayfong;Taylor, Ann M.;Newton, Paul N.
目的：在泰国，维生素B1缺乏使严重的恶性疟原虫疟疾变得复杂，并可能导致酸中毒。因此，我们估计的频率生化硫胺素缺乏症的患者提出与单纯恶性疟在老挝南部。方法红细胞转酮醇酶活化系数（α）进行了测量，在310例患者提出与单纯恶性疟和42天后开始治疗。结果12%的患者有严重的缺乏生化证据（α值> 1.31），42天后下降至3%.CONCLUSION老挝患者因无并发症恶性疟原虫感染而入院时，维生素B1缺乏症很常见，经疟疾和多种维生素补充治疗后，维生素B1缺乏症减少。这种可预防和可治疗的疾病在疟疾和其他急性感染中的作用，以及老挝农村脚气病的发病率，需要进一步调查。
OBJECTIVE Thiamin deficiency complicates severe Plasmodium falciparum malaria in Thailand and may contribute to acidosis. We therefore estimated the frequency of biochemical thiamin deficiency in patients presenting with uncomplicated falciparum malaria in southern Laos.METHODS Red cell transketolase activation coefficients (alpha) were measured in 310 patients presenting with uncomplicated falciparum malaria and 42 days after starting treatment.RESULTS Twelve per cent of patients had biochemical evidence of severe deficiency (alpha values > 1.31) at presentation, declining to 3% 42 days later.CONCLUSION Thiamin deficiency was common in Lao patients admitted with uncomplicated P. falciparum infection and was reduced following treatment of malaria and multivitamin supplementation. The role of this preventable and treatable disorder in malaria and other acute infections, and the incidence of beriberi in rural Laos, needs further investigation.