Body size throughout adult life influences postmenopausal breast cancer risk among hispanic women: the breast cancer health disparities study.
Body size throughout adult life influences postmenopausal breast cancer risk among hispanic women: the breast cancer health disparities study.
复制标题
DOI：
10.1158/1055-9965.epi-14-0560
复制
发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Slattery ML
中科院分区：
文献类型：
--
作者：
John EM;Sangaramoorthy M;Hines LM;Stern MC;Baumgartner KB;Giuliano AR;Wolff RK;Slattery ML
很少有研究评估西班牙裔女性的体型与绝经后乳腺癌(BC)风险的关系。研究结果并不一致，而且似乎与非西班牙裔白人(NHW)女性的研究报告相矛盾。我们汇集了2,023名西班牙裔和2,384名nhw女性的采访和人体测量数据，这些数据来自两项基于美国人口的病例对照研究。使用Logistic回归分析，我们检验了总体和腹部肥胖与绝经后BC风险的关系，该风险由雌激素受体(ER)和孕激素受体(PR)状态定义。在目前没有使用更年期激素治疗(HT)的西班牙裔美国人中，体重增加与ER+PR+BC的风险增加有关，但仅在那些年轻成年人体重指数(BMI)较低的人中。在具有遗传血统数据的拉美裔子集中，与体重增加的联系仅限于具有较低美洲原住民血统的女性。青壮年BMI与ER+PR+和ER-PR-BC呈负相关，在西班牙裔和NHW中有相似但不显著的相反趋势。在所有拉美裔人中，无论使用哪种羟色胺，身高与ER-PR-BC的风险相关，臀围与BC的总体风险相关。在绝经后的西班牙裔女性中，成年后的体型与患BC的风险有关，这一点已经在NHW女性中报道。关联是由激素受体状态定义的BC亚型特有的。避免体重增加和保持健康的体重是降低绝经后ER+PR+BC风险的重要策略，ER+PR+BC是最常见的BC亚型。
Few studies have assessed the association of body size with postmenopausal breast cancer (BC) risk in Hispanic women. Findings are inconsistent and appear to contradict those reported for non-Hispanic White (NHW) women. We pooled interview and anthropometric data for 2,023 Hispanic and 2,384 NHW women from two U.S. population-based case-control studies. Using logistic regression analysis, we examined associations of overall and abdominal adiposity with risk of postmenopausal BC defined by estrogen receptor (ER) and progesterone receptor (PR) status. Weight gain was associated with increased risk of ER+PR+ BC in Hispanics not currently using menopausal hormone therapy (HT), but only among those with a low young-adult body mass index (BMI). In the subset of Hispanics with data on genetic ancestry, the association with weight gain was limited to women with lower Indigenous American ancestry. Young-adult BMI was inversely associated with both ER+PR+ and ER-PR- BC for both ethnicities combined, with similar, although non-significant, inverse trends in Hispanics and NHWs. Among all Hispanics, regardless of HT use, height was associated with risk of ER-PR-BC and hip circumference with risk of BC overall. Body size throughout adult life is associated with BC risk among postmenopausal Hispanic women, as has been reported for NHW women. Associations were specific for BC subtypes defined by hormone receptor status. Avoiding weight gain and maintaining a healthy weight are important strategies to reduce the risk of postmenopausal ER+PR+ BC, the most common BC subtype.