Harnessing the antigenic fingerprint of each individual cancer for immunotherapy of human cancer: genomics shows a new way and its challenges.
Harnessing the antigenic fingerprint of each individual cancer for immunotherapy of human cancer: genomics shows a new way and its challenges.
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DOI：
10.1007/s00262-013-1422-x
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发表时间：
2013-05
影响因子：
5.8
通讯作者：
Duan, Fei
中科院分区：
文献类型：
--
作者：
Srivastava, Pramod K.;Duan, Fei
自从我们认识到对肿瘤的适应性免疫反应以来，个体肿瘤在抗原性上是独特的这一想法就一直存在。这一想法激发了人类癌症个体化免疫疗法的少量尝试。由于技术上的困难，这种先前针对实体瘤的尝试由于无法定义肿瘤的个体独特抗原库而受到阻碍。快速廉价的高通量DNA测序有望克服这一障碍。使用这种新的能力，加上生物信息学工具，现在可以在实际的时间范围内和可接受的成本内以高度的粒度定义任何肿瘤的免疫原性库。这些想法的发展，并强调这一承诺的少数这样的研究，进行了讨论。这种通过肿瘤基因组特征来表征肿瘤免疫组的新方法具有独特的挑战，包括选择合适的肽，选择可以包含数十个表位的免疫方法，以及解决肿瘤抗原异质性的问题。然而，应对这些挑战的工具已经存在，而且正在出现。
The idea that individual tumors are antigenically unique has been around since the very dawn of our recognition of adaptive immune response to tumors. That idea has inspired a small number of attempts at individualized immunotherapy of human cancers. Such previous attempts for solid tumors have been hobbled by an inability to define the individually unique antigenic repertoire of tumors because of technological difficulties. The new availability of rapid and cheap high throughput DNA sequencing promises to overcome that hurdle. Using this new ability, coupled with bio-informatic tools, it is now possible to define the immunogenic repertoire of any tumor to a high degree of granularity within a practical time frame and an acceptable cost. The development of these ideas, and a small number of such studies that underscore this promise, is discussed. This new way—of characterizing the tumor immunome through characterization of the tumor genome—has distinct challenges, including selection of the appropriate peptides, choosing methods of immunizations that can incorporate tens of epitopes, and addressing issues of antigenic heterogeneity of tumors. However, tools for meeting these challenges exist and are emergent.
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DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
7.8
作者：
Buckwalter MR;Srivastava PK
通讯作者：
Srivastava PK
DOI：
10.1084/jem.185.4.695
发表时间：
1997-02-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dubey P;Hendrickson RC;Meredith SC;Siegel CT;Shabanowitz J;Skipper JC;Engelhard VH;Hunt DF;Schreiber H
通讯作者：
Schreiber H
影响因子：
158.5
作者：
Kantoff, Philip W.;Higano, Celestia S.;Young, J.
通讯作者：
Young, J.
影响因子：
6.8
作者：
Faries, MB;Morton, DL
通讯作者：
Morton, DL