EFFECTS OF EARLY-LIFE STRESS ON COGNITIVE FUNCTION AND HIPPOCAMPAL STRUCTURE IN FEMALE RODENTS
EFFECTS OF EARLY-LIFE STRESS ON COGNITIVE FUNCTION AND HIPPOCAMPAL STRUCTURE IN FEMALE RODENTS
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DOI：
10.1016/j.neuroscience.2015.08.024
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发表时间：
2017-02-07
期刊：
影响因子：
3.3
通讯作者：
Joels, M.
中科院分区：
文献类型：
--
作者：
Loi, M.;Mossink, J. C. L.;Joels, M.
我们测试了早期生活应激（ELS）-产后第3天（PND）24小时母亲剥夺（MD）-对12-17周龄雌性大鼠认知能力和海马结构的影响。行为表现进行了检查：高架加迷宫，作为一般性焦虑的指数;啮齿动物爱荷华州赌博测试，探测奖励为基础的决策;和物体识别和物体定位任务，以评估非压力的上下文记忆性能。我们进一步确定海马齿状回（DG）的体积和细胞密度，以及成人增殖和神经发生率。一半的大鼠在关键的青春期前发育窗口（PND 26-28）期间接受糖皮质激素受体拮抗剂米非司酮治疗，试图改善ELS的潜在不良行为后果。无论是MD也不治疗与糖皮质激素拮抗剂影响行为表现的女性在任何任务。此外，DG结构，增殖和神经发生组之间没有差异。在非应激海马依赖性学习任务中缺乏结构差异和行为表型与女性ELS后通常报告的缺乏表型相吻合，但在男性啮齿动物中则较少。从大量的文献综述中可以看出，在进行焦虑相关任务的测试时，雌性和雄性动物对早期生活逆境的反应似乎更相似。这与最近在人类中的研究结果一致，表明女性可能对儿童期虐待的结构/海马影响具有相对弹性，但对儿童期虐待被认为是风险因素的焦虑和情绪相关的精神病理学没有弹性。(C)2015年IBRO。由爱思唯尔有限公司出版。保留所有权利。
We tested the effect of early-life stress (ELS) - 24 h maternal deprivation (MD) at postnatal day (PND) 3 - on cognitive performance and hippocampal structure in 12-17-week-old female rats. Behavioral performance was examined in: the Elevated Plus Maze, as an index for general anxiety; the rodent Iowa gambling test, probing reward-based decision making; and the object recognition and object-in-location task, to assess non-stressful contextual memory performance. We further determined hippocampal dentate gyrus (DG) volume and cell density as well as adult proliferation and neurogenesis rates. Half of the rats was treated with the glucocorticoid receptor antagonist mifepristone during a critical pre-pubertal developmental window (PNDs 26-28), in an attempt to ameliorate the potentially adverse behavioral consequences of ELS. Neither MD nor treatment with the glucocorticoid antagonist affected behavioral performance of the females in any of the tasks. Also, DG structure, proliferation and neurogenesis were not different between the groups. Lack of structural differences and a behavioral phenotype in non-stressful hippocampus dependent learning tasks fits with the lack of phenotype generally reported after ELS in female but less so in male rodents. As evident from an extensive literature review, female and male animals appear to respond more similarly to early-life adversity when tested in anxiety-related tasks. This agrees with recent findings in humans suggesting that females may be relatively resilient to the structural/hippocampal effects of childhood maltreatment, but not to the anxiety and mood-related psychopathology for which childhood maltreatment is considered a risk factor. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.