A novel synthetic tissue-adhesive hydrogel using a crosslinkable polymeric micelle
A novel synthetic tissue-adhesive hydrogel using a crosslinkable polymeric micelle
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DOI：
10.1002/jbm.a.30911
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发表时间：
2007-02-01
影响因子：
4.9
通讯作者：
Kurosawa, Hiromi
中科院分区：
文献类型：
--
作者：
Murakami, Yoshihiko;Yokoyama, Masayuki;Kurosawa, Hiromi
我们通过使用一种由端接聚乙二醇-聚乳酸（PEG-PLA）嵌段聚合物组成的聚合物胶束制备了一种新型的组织粘附性水凝胶。聚烯丙基胺中的氨基与聚合物胶束表面上的醛基之间化学形成席夫碱。当聚合物胶束溶液和聚烯丙基胺溶液在体外混合时，水凝胶在类似于2s内形成。该水凝胶在体内快速形成，并粘附到组织表面。我们的新型组织粘合水凝胶不会产生感染性污染的风险，因为它仅由合成材料组成。此外，已知PEG和PLA具有生物相容性和非细胞毒性。在本研究中获得的结果表明，通过在醛基和胺基之间形成席夫碱制备的水凝胶将潜在地解决对新型组织粘附材料的需求。(c)2006 Wiley Periodicals，Inc.
We prepared a novel tissue-adhesive hydrogel by using a polymeric micelle consisting of an aldehyde-terminated poly(ethylene glycol)-poly(D,L-lactide) (PEG-PLA) block polymer. A Schiff base is chemically formed between the amino groups in a polyallylamine and the aldehyde groups on the surface of polymeric micelles. The hydrogel was formed in similar to 2 s when the polymeric micelle solution and polyallylamine solution are mixed in vitro. The hydrogel was rapidly formed in vivo, and it adhered to a tissue surface. Our novel tissue-adhesive hydrogel creates no risk of infectious contaminations, because it consists of only synthetic materials. Further, PEG and PLA are known to be biocompatible and noncytotoxic. The results obtained in the present study show that a hydrogel prepared by the formation of a Schiff base between aldehyde and amine groups will potentially address the need for novel tissue-adhesive materials. (c) 2006 Wiley Periodicals, Inc.