Rubesanolides C-E: abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity
Rubesanolides C-E: abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity
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DOI：
10.1039/c2ob25192b
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发表时间：
2012-01-01
影响因子：
3.2
通讯作者：
Sun, Handong
中科院分区：
文献类型：
--
作者：
Zou, Juan;Pan, Lutai;Sun, Handong
对药用植物冬凌草的叶进行了植物化学研究，分离得到了三个新的松烷二萜类化合物：冬凌草内酯C-E(1-3)。这些二萜化合物含有在C-8和C-20之间形成的独特的-内酯亚基。通过光谱分析确定了它们的结构，并用X-射线单晶数据进一步证实了它们的结构。对化合物的抗菌活性进行了评价，发现橡胶内酯D(2)对牙科细菌变形链球菌的生物被膜有抑制作用。
Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique.-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.