Intact HIV reservoir estimated by the intact proviral DNA assay correlates with levels of total and integrated DNA in the blood during suppressive antiretroviral therapy.
Intact HIV reservoir estimated by the intact proviral DNA assay correlates with levels of total and integrated DNA in the blood during suppressive antiretroviral therapy.
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DOI：
10.1093/cid/ciaa809
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发表时间：
2020-06-18
期刊：
影响因子：
--
通讯作者：
Montaner, Luis J
中科院分区：
文献类型：
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作者：
Papasavvas, Emmanouil;Azzoni, Livio;Montaner, Luis J
准确描述艾滋病毒储存库对于开发有效的治疗方法至关重要。使用完整原病毒 DNA 测定 (IPDA) 以及总或整合的 HIV DNA 测定以及诱导型 HIV RNA 或 p24 测定，在抗逆转录病毒治疗抑制的个体中测量 HIV。完整的原病毒与总的和综合的艾滋病毒相关。
Accurate characterization of the HIV reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.