Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: An experiment of nature
Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: An experiment of nature
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DOI：
10.1086/498980
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发表时间：
2006-01-01
影响因子：
6.4
通讯作者：
Epstein, SL
中科院分区：
文献类型：
--
作者：
Epstein, SL
在大流行期间，依靠中和抗体来对抗匹配病毒的流感疫苗可能无法及早获得。在动物中观察到更广泛的（异亚型）免疫保护。人类也有交叉亚型免疫吗？为了调查这个问题，我们分析了克利夫兰家庭研究的档案记录，该研究在1957年大流行之前和期间进行（在此期间发生了从H1N1亚型到H2N2亚型的转变）。在早期研究中，只有5.6%有甲型流感症状的成年人在大流行期间发展为流感，尽管他们与患有流感的参与者生活在一起。相比之下，55.2%有过甲型流感症状的儿童再次感染。这些发现表明在大流行期间积累的异亚型免疫的影响。这种免疫力及其对疫苗接种的影响应进一步研究。
During a pandemic, influenza vaccines that rely on neutralizing antibodies to protect against matched viruses might not be available early enough. Much broader (heterosubtypic) immune protection is seen in animals. Do humans also have cross-subtype immunity? To investigate this issue, archival records from the Cleveland Family Study, which was conducted before and during the 1957 pandemic (during which a shift from subtype H1N1 to H2N2 occurred), were analyzed. Only 5.6% of the adults who had had symptomatic influenza A in earlier study years developed influenza during the pandemic, despite living in households with participants who had influenza. In contrast, 55.2% of the children who had had symptomatic influenza A contracted it again. These findings suggest an impact of accumulated heterosubtypic immunity during a pandemic. Such immunity, as well as its implications for vaccination, should be further investigated.