Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI
Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI
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DOI：
10.1016/j.ejrad.2015.10.018
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发表时间：
2016-01-01
影响因子：
3.3
通讯作者：
Shirato, Hiroki
中科院分区：
文献类型：
--
作者：
Kato, Fumi;Kudo, Kohsuke;Shirato, Hiroki
目的：比较不同乳腺癌亚型的形态学及最小表观扩散系数（ADC）值。方法：93例经乳腺MRI检查，病理证实有98例浸润性癌的患者入选。根据BIRADS-MRI评估形态学。测量最小ADC。各亚型间形态学及最小ADC比较。采用多变量logistic回归分析来确定与不同亚型相关的特征。结果：椭圆/圆形与三阴性（TN）癌显著相关（TN vs.非TN: 90.9% vs. 45.2%; p = 0.0123）。Luminal A组边缘增强的频率明显较低（Luminal A vs.非Luminal A: 34.2% vs. 76.1%; p = 0.0003）。Luminal A的最小ADC显著高于Luminal B （her2阴性）(834 vs. 748 × 10(-6) mm(2)/s)；p
Purpose: To compare the morphology and minimum apparent diffusion coefficient (ADC) values among breast cancer subtypes.Methods: Ninety-three patients, who underwent breast MRI and collectively had 98 pathologically proven invasive carcinomas, were enrolled. Morphology was evaluated according to BIRADS-MRI. Minimum ADC was measured. Morphology and minimum ADC were compared among subtypes. Multivariate logistic regression analyses were used to identify the characteristics associated with different subtypes.Results: Oval/round shape was significantly associated with triple-negative (TN) cancer (TN vs. non-TN: 90.9% vs. 45.2%; p = 0.0123). Rim enhancement was significantly less frequent in Luminal A (Luminal A vs. non-Luminal A: 34.2% vs. 76.1%; p = 0.0003). The minimum ADC of Luminal A was significantly higher than that of Luminal B (HER2-negative) (834 vs. 748 x 10(-6) mm(2)/s; p