Osteoarthritis: Frzb knockout reveals the complexity of Wnt signaling in joint homeostasis.
Osteoarthritis: Frzb knockout reveals the complexity of Wnt signaling in joint homeostasis.
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DOI：
10.1038/nrrheum.2012.15
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发表时间：
2012-02-07
期刊：
影响因子：
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通讯作者：
Killock, David
中科院分区：
文献类型：
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作者：
Killock, David
“这些数据证实，关节中软骨-骨单位中的Wnt信号传导受到严格调控，”Lories说，“这可能解释了为什么Frzb-/-小鼠似乎不会自发发展OA。这些发现也可能部分解释FRZB与人类OA之间不一致的关联。“关节中的补偿机制是复杂的，软骨保护策略是一个真实的挑战，”Lories说。然而，Wnt通路代表了OA治疗的有吸引力的靶点。
“These data confirm that Wnt signaling in the cartilage‑bone unit in the joint is tightly regulated,” says Lories, and “may provide an explanation why Frzb–/–mice do not appear to spontaneously develop OA.” These findings might also partially explain the inconsistent association of FRZB with OA in humans.“Compensatory mechanisms in the joint are complex and chondroprotective strategies represent a real challenge,” states Lories. Nevertheless, the Wnt pathway represents an attractive target for therapy in OA.