The Ebolavirus VP24 Protein Blocks Phosphorylation of p38 Mitogen-Activated Protein Kinase
The Ebolavirus VP24 Protein Blocks Phosphorylation of p38 Mitogen-Activated Protein Kinase
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DOI：
10.1093/infdis/jir325
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发表时间：
2011-11-01
影响因子：
6.4
通讯作者：
Kawaoka, Yoshihiro
中科院分区：
文献类型：
--
作者：
Halfmann, Peter;Neumann, Gabriele;Kawaoka, Yoshihiro
I型干扰素（IFN）信号是通过多种信号通路介导的，包括Janus激酶和信号换能器和激活器（JAK-STAT）和p38丝裂原活化蛋白（MAP）激酶途径。埃博拉病毒的VP24蛋白是一种IFN拮抗剂，通过JAK-STAT途径阻断I型IFN信号。本研究表明，在293细胞中，VP24也通过阻断ifn - β刺激的p38- α磷酸化来干扰p38 MAP激酶途径。在HeLa细胞中没有观察到类似的抑制，提示信号转导的细胞类型特异性差异。
Type I interferon (IFN) signaling is mediated through several signaling pathways, including the Janus kinase and signal transducer and activator (JAK-STAT) and p38 mitogen-activated protein (MAP) kinase pathways. The VP24 protein of Ebolavirus is an IFN antagonist, blocking type I IFN signaling through the JAK-STAT pathway. Here, we show that, in 293 cells, VP24 also interferes with the p38 MAP kinase pathway by blocking IFN-beta-stimulated phosphorylation of p38-alpha. Similar inhibition was not observed in HeLa cells, suggesting cell type-specific differences in signal transduction.