Why are proteins marginally stable?
Why are proteins marginally stable?
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DOI：
10.1002/prot.10016
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Goldstein, RA
中科院分区：
文献类型：
--
作者：
Taverna, DM;Goldstein, RA
无论大小或活性如何，大多数球状蛋白都具有一定的稳定性。最常见的解释是蛋白质必须保持边缘稳定才能发挥作用，因此边缘稳定性代表了正选择的结果。我们直接使用模型蛋白质和群体中蛋白质进化的动力学方面来考虑边际稳定性问题。我们发现，由于序列空间的高维性，蛋白质的边际稳定性是蛋白质的固有属性，而不考虑蛋白质功能。这样，中性的、非适应性的进化就可以产生边际稳定性。通过允许具有不同功能稳定性要求的不断进化的蛋白质亚群完成，我们发现边缘稳定的蛋白质群体往往占主导地位。我们的结果表明，与边际稳定性一致的功能具有很强的进化优势，并且可能是由于蛋白质倾向于边际稳定性的自然倾向而出现的。蛋白质 2002；46：105-109。 (C) 2001 Wiley-Liss, Inc.
Most globular proteins are marginally stable regardless of size or activity. The most common interpretation is that proteins must be marginally stable in order to function, and so marginal stability represents the results of positive selection. We consider the issue of marginal stability directly using model proteins and the dynamical aspects of protein evolution in populations. We find that the marginal stability of proteins is an inherent property of proteins due to the high dimensionality of the sequence space, without regard to protein function. In this way, marginal stability can result from neutral, non-adaptive evolution. By allowing evolving protein sub-populations with different stability requirements for functionality to complete, we find that marginally stable populations of proteins tend to dominate. Our results show that functionalities consistent with marginal stability have a strong evolutionary advantage, and might arise because of the natural tendency of proteins towards marginal stability. Proteins 2002;46:105-109. (C) 2001 Wiley-Liss, Inc.