AFRICAN POPULATIONS AND THE EVOLUTION OF HUMAN MITOCHONDRIAL-DNA
AFRICAN POPULATIONS AND THE EVOLUTION OF HUMAN MITOCHONDRIAL-DNA
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DOI：
10.1126/science.1840702
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发表时间：
1991-09-27
期刊：
影响因子：
56.9
通讯作者：
WILSON, AC
中科院分区：
文献类型：
--
作者：
VIGILANT, L;STONEKING, M;WILSON, AC
当代人类的所有线粒体DNA（mtDNA）类型都来自大约20万年前非洲人口的共同祖先，这一提议引起了人们的广泛关注。 为了进一步研究这一提议，对189名不同地理来源的人（包括121名非洲土著人）的线粒体DNA的两个高变片段进行了测序。 观察到的地理特异性，相同的mtDNA类型是共享的，但不是种群之间。 将这些线粒体DNA序列相互关联起来，并与黑猩猩的序列关联起来的树有许多深分支，专门指向非洲人的线粒体DNA。 人类mtDNA的非洲起源得到了两个统计检验的支持。 通过使用黑猩猩和人类的序列来校准mtDNA进化的速度，人类共同mtDNA祖先的年龄被放置在166，000和249，000之间。 这些结果支持并扩展了人类mtDNA进化的非洲起源假说。
The proposal that all mitochondrial DNA (mtDNA) types in contemporary humans stem from a common ancestor present in an African population some 200,000 years ago has attracted much attention. To study this proposal further, two hypervariable segments of mtDNA were sequenced from 189 people of diverse geographic origin, including 121 native Africans. Geographic specificity was observed in that identical mtDNA types are shared within but not between populations. A tree relating these mtDNA sequences to one another and to a chimpanzee sequence has many deep branches leading exclusively to African mtDNAs. An African origin for human mtDNA is supported by two statistical tests. With the use of the chimpanzee and human sequences to calibrate the rate of mtDNA evolution, the age of the common human mtDNA ancestor is placed between 166,000 and 249,000 years. These results thus support and extend the African origin hypothesis of human mtDNA evolution.