Preoperative plasma endoglin levels predict biochemical progression after radical prostatectomy.
Preoperative plasma endoglin levels predict biochemical progression after radical prostatectomy.
复制标题
术前血浆内皮糖蛋白水平可预测根治性前列腺切除术后的生化进展。
DOI：
10.1158/1078-0432.ccr-07-4707
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Shariat,ShahrokhF
中科院分区：
文献类型：
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作者：
Svatek,RobertS;Karam,JoseA;Roehrborn,ClausG;Karakiewicz,PierreI;Slawin,KevinM;Shariat,ShahrokhF
目的：内皮素（Endoglin, CD105）是人血管内皮细胞表达的一种跨膜糖蛋白，被认为在内皮细胞增殖中起关键作用。本研究的目的是评估术前血浆内啡肽水平与前列腺癌的临床和病理特征以及根治性前列腺切除术后疾病进展的关系。实验设计：采用市售ELISA法测定425例接受根治性前列腺切除术的临床局限性前列腺癌患者的术前血浆内啡肽水平。采用多因素logistic回归检验根治性前列腺切除术后血浆内啡肽水平与生化进展的关系。结果：分析时存活患者的中位随访时间为36.8个月（四分位数间距为44.1）。425例患者中，77例（18.1%）在根治性前列腺切除术后出现生化进展。术前总血清前列腺特异性抗原较高（P< 0.001）和不良病理特征的患者术前血浆内啡肽水平显著升高。在调整标准术前和术后特征的影响后，术前血浆内啡肽是术后生化进展的独立预测因子（P< 0.001和P= 0.026）。结论：术前血浆内啡肽水平与晚期前列腺癌的既定特征相关。更重要的是，术前较高的血浆内啡肽水平是根治性前列腺切除术和双侧盆腔淋巴结切除术患者生化进展风险增加的独立预测因素。
Purpose:Endoglin (CD105) is a transmembrane glycoprotein expressed by human vascular endothelial cells thought to play a pivotal role in endothelial cell proliferation. The aim of this study was to evaluate the association of preoperative plasma endoglin levels with established clinical and pathologic features of prostate cancer and disease progression after radical prostatectomy.Experimental Design:Preoperative plasma endoglin levels were measured in 425 patients who underwent radical prostatectomy for clinically localized prostate cancer using a commercially available ELISA assay. Multivariate logistic regression was used to test the association of plasma endoglin levels with biochemical progression after radical prostatectomy.Results:Median follow-up for patients alive at the time of analysis was 36.8 months (interquartile range, 44.1). Of 425 patients, 77 patients (18.1%) experienced biochemical progression after radical prostatectomy. Preoperative plasma endoglin levels were significantly elevated in patients with higher preoperative total serum prostate-specific antigen (P< 0.001) and adverse pathologic features. Preoperative plasma endoglin was an independent predictor of biochemical progression after surgery after adjusting for the effects of standard preoperative and postoperative features (P< 0.001 andP= 0.026, respectively).Conclusions:Preoperative plasma endoglin levels are associated with established features of advanced prostate cancer. More importantly, higher preoperative plasma endoglin levels are independent predictors of an increased risk of biochemical progression in patients treated with radical prostatectomy and bilateral pelvic lymphadenectomy.