Metformin treatment is effective in obese teenage girls with PCOS
Metformin treatment is effective in obese teenage girls with PCOS
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DOI：
10.1093/humrep/del185
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发表时间：
2006-09-01
影响因子：
6.1
通讯作者：
Petraglia, F.
中科院分区：
文献类型：
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作者：
De Leo, Vincenzo;Musacchio, M. C.;Petraglia, F.
背景：多囊卵巢综合征（PCOS）是少女月经紊乱的最常见原因。关于二甲双胍对青春期多囊卵巢综合征（PCOS）女孩的影响及其剂量和调节月经周期和高雄激素症状的功效的信息很少。我们评估了二甲双胍治疗对多囊卵巢综合征青春期女孩的排卵功能、多毛、痤疮、激素模式和体重的影响。方法：18名年龄在15至18岁之间的女孩被纳入研究。多囊卵巢综合征的临床诊断基于2003年5月在鹿特丹接受的多囊卵巢综合征的共识标准。所有受试者服用片剂二甲双胍1700 mg/d，连续6个月。然后对他们进行了6个月的随访。结果：2例患者在用药2周后出现不良反应，中断治疗；他们没有被评估。其他所有人的月经周期都有所改善。月经期为排卵期，黄体期黄体酮水平高达6 ng/ml，睾酮、雄烯二酮和游离睾酮显著降低。BMI在21 ~ 24 kg/m之间的所有女孩恢复到正常范围内(2)。二甲双胍治疗结束6个月后，月经周期继续规律，排卵BMI正常。副作用很轻微。结论：目前的研究结果证实了二甲双胍对月经期的积极作用，并表明该药物可用于年轻女性，以改善排卵和多毛、痤疮和体重增加等高雄激素症状。
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most frequent cause of menstrual disorders in teenage girls. Little information is available about the effects of metformin in adolescent girls with PCOS and its dose and its efficacy in regulating menstrual cyclicity and hyperandrogenic symptoms. We evaluated the effects of metformin treatment on ovulatory function, hirsutism, acne, hormonal patterns and body weight in adolescent girls with PCOS. METHODS: Eighteen girls, ranging in age from 15 to 18 years, were enrolled in the study. Clinical diagnosis of PCOS was based on the consensus criteria for PCOS accepted in May 2003 at Rotterdam. All subjects received 1700 mg/day metformin as tablets continuously for 6 months. They were then followed up for 6 months. RESULTS: Two patients complained of side effects for > 2 weeks and interrupted treatment; they were not evaluated. All the others showed an improvement in menstrual cyclicity. Menstrual periods were ovulatory, with progesterone levels up to 6 ng/ml in luteal phase and a significant reduction in testosterone, androstenedione and free testosterone. BMI was restored within normal limits in all girls between 21 and 24 kg/m(2). Six months after the end of metformin treatment, menstrual cycles continued to be regular and ovulatory with normal BMI. Side effects were slight. CONCLUSIONS: The present results confirm the positive effects of metformin on menstrual periods and show that the drug can be administered to young women to improve ovulation and hyperandrogenic symptoms such as hirsutism, acne and weight gain.