Epileptic Activity Intrinsically Generated in the Human Cerebellum.
Epileptic Activity Intrinsically Generated in the Human Cerebellum.
复制标题
人类小脑内在产生的癫痫活动。
DOI：
10.1002/ana.25779
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发表时间：
2020
影响因子：
11.2
通讯作者：
Pearl,PhillipL
中科院分区：
文献类型：
--
作者：
Okada,Yoshio;Khan,Sheraz;Curran,Ashley;Ahtam,Banu;Hämäläinen,MattiS;Traub,RogerD;Pearl,PhillipL
脑干和小脑中的肿瘤或发育不良的神经元组织可能会导致儿科患者癫痫发作。然而，尚不清楚这种组织是否可以改变人类小脑的内在特性，使其能够产生癫痫群体活动。我们在一名因小脑中脚肿瘤而患有癫痫的儿科患者中，无创地检测到了未平均的癫痫样信号。对信号发生器的分析表明，肿瘤同侧和对侧小脑是主要的发作间期尖峰发生器，并且可以引发发作活动，这表明人类小脑可能能够内在地产生癫痫活动。ANN NEUROL 2020；88：418-422。
Neoplastic or dysplastic neuronal tissue in the brain stem and cerebellum can become epileptogenic in pediatric patients. However, it is unknown whether such tissue may transform intrinsic properties of the human cerebellum, making it capable of generating epileptic population activity. We noninvasively detected epileptiform signals unaveraged in a pediatric patient with epilepsy due to a tumor in the middle cerebellar peduncle. Analysis of generators of the signals revealed that the cerebellum ipsilateral and contralateral to the tumor was the dominant interictal spike generator and could initiate ictal activity, suggesting that human cerebellum may become capable of intrinsically generating epileptic activity.ANN NEUROL 2020;88:418–422.