A better prognosis for genetic association studies in mice.
A better prognosis for genetic association studies in mice.
复制标题
小鼠遗传关联研究的更好预后。
DOI：
10.1016/j.tig.2011.10.006
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Peltz,Gary
中科院分区：
文献类型：
--
作者：
Zheng,Ming;Dill,David;Peltz,Gary
Although inbred mouse strains have been the premier model organism used in biomedical research, multiple studies and analyses have indicated that genome-wide association studies (GWAS) cannot be productively performed using inbred mouse strains. However, there is one type of GWAS in mice that has successfully identified the genetic basis for many biomedical traits of interest: haplotype-based computational genetic mapping (HBCGM). Here, we describe how the methodological basis for a HBCGM study significantly differs from that of a conventional murine GWAS, and how an integrative analysis of its output within the context of other ‘omic' information can enable genetic discovery. Consideration of these factors will substantially improve the prognosis for the utility of murine genetic association studies for biomedical discovery.
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影响因子：
4.5
作者：
Yalcin B;Nicod J;Bhomra A;Davidson S;Cleak J;Farinelli L;Østerås M;Whitley A;Yuan W;Gan X;Goodson M;Klenerman P;Satpathy A;Mathis D;Benoist C;Adams DJ;Mott R;Flint J
通讯作者：
Flint J
DOI：
--
发表时间：
2006
期刊：
影响因子：
--
作者：
Voigt B;Kuramoto T;Tsurumi T;Mashimo T;Sasaki Y;Hokao R;Serikawa T
通讯作者：
Serikawa T
小鼠计算遗传图谱：船已经起航
影响因子：
17.1
作者：
M. Zheng;S. Shafer;Guochun Liao;Hong;G. Peltz
通讯作者：
G. Peltz
影响因子：
4.4
作者：
Reuveni, Eli;Birney, Ewan;Gross, Cornelius T.
通讯作者：
Gross, Cornelius T.
影响因子：
64.8
作者：
Flint, Jonathan;Mott, Richard
通讯作者：
Mott, Richard