Cellular Automaton Model of a Tumor Tissue Consisting of Tumor Cells, Cytotoxic T Lymphocytes (CTLs), and Cytokine Produced by CTLs
Cellular Automaton Model of a Tumor Tissue Consisting of Tumor Cells, Cytotoxic T Lymphocytes (CTLs), and Cytokine Produced by CTLs
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由肿瘤细胞、细胞毒性 T 淋巴细胞 (CTL) 和 CTL 产生的细胞因子组成的肿瘤组织的细胞自动机模型
DOI：
10.2197/ipsjdc.2.138
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
A. Ohuchi
中科院分区：
文献类型：
--
作者：
T. Takayanagi;H. Kawamura;A. Ohuchi
我们提出了一种肿瘤组织的细胞自动机模型，由方格、肿瘤细胞、细胞毒性 T 淋巴细胞 (CTL) 和细胞因子组成。考虑到CTL在体内循环并迁移到肿瘤组织中，该正方形是开放的并且CTL在该正方形中移动。通过元胞自动机模型的计算，我们得到了这样的结果：一团被CTL包围的肿瘤细胞生长； CTL 对肿瘤细胞的排斥；以及肿瘤细胞和 CTL 之间的近似平衡。结果分析表明肿瘤细胞和CTL之间的附着对于CTL排斥肿瘤细胞很重要。
We propose a cellular automaton model of a tumor tissue consisting of a square lattice, tumor cells, cytotoxic T lymphocytes (CTLs) and cytokine. Considering that CTLs circulate in vivo and migrate into a tumor tissue, the square is open and CTLs move through the square. By calculating the cellular automaton model, we obtained these results: the growth of a mass of tumor cells surrounded by CTLs; the rejection of tumor cells by CTLs; and an approximate equilibrium between tumor cells and CTLs. Analysis of the results indicates that the attachment between tumor cells and CTLs is important for the rejection of tumor cells by CTLs.
影响因子：
3.5
作者：
KUZNETSOV, VA;MAKALKIN, IA;PERELSON, AS
通讯作者：
PERELSON, AS