The Finnish Adoptive Family Study of Schizophrenia
The Finnish Adoptive Family Study of Schizophrenia
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芬兰收养家庭对精神分裂症的研究
DOI：
10.1192/s0007125000292696
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发表时间：
1994
影响因子：
10.5
通讯作者：
K. Läksy
中科院分区：
文献类型：
--
作者：
P. Tienari;L. Wynne;J. Moring;I. Lahti;M. Naarala;A. Sorri;K. Wahlberg;O. Saarento;M. Seitamaa;M. Kaleva;K. Läksy
在芬兰全国范围内，将精神分裂症患者的后代与匹配的对照组进行了盲法比较，后者是非精神分裂症亲生父母的后代。采用联合和单独访谈以及心理测试对收养家庭进行了彻底调查。亲生父母也接受了采访和测试。在155名指数后代中，精神病和其他严重诊断（边缘综合征和严重人格障碍）的百分比显着高于186名匹配的对照收养者。这支持了一个遗传假说。然而，这两组之间的显着差异只出现在被评为不安的家庭。因此，遗传效应（即高遗传倾向和低遗传倾向之间的差异）只有在家庭环境受到干扰的情况下才表现为精神障碍。干扰的家庭关系的影响是最强的存在适当的基因型。
A nationwide Finnish sample of schizophrenics' offspring given up for adoption was compared blindly with matched controls, who were adopted offspring of non-schizophrenic biological parents. The adoptive families were investigated thoroughly using joint and individual interviews and psychological tests. The biological parents were also interviewed and tested. Among the 155 index offspring, the percentage of both psychoses and other severe diagnoses (borderline syndrome and severe personality disorders) was significantly higher than in the 186 matched control adoptees. This supports a genetic hypothesis. However, notable differences between these two groups only emerged in the families which were rated as disturbed. Thus the genetic effect (i.e. the differences between high and low genetic propensity) was only manifested as a psychiatric disorder in the presence of a disturbed family environment. The impact of disturbed family relations was strongest in the presence of the appropriate genotype.
影响因子：
6.6
作者：
NUECHTERLEIN, KH;DAWSON, ME
通讯作者：
DAWSON, ME
影响因子：
--
作者：
Shenton,ME;Solovay,MR;Holzman,P
通讯作者：
Holzman,P
影响因子：
--
作者：
Solovay,MR;Shenton,ME;Holzman,PS
通讯作者：
Holzman,PS