Adenosquamous Carcinoma of the Head and Neck: A Case–Control Study with Conventional Squamous Cell Carcinoma
Adenosquamous Carcinoma of the Head and Neck: A Case–Control Study with Conventional Squamous Cell Carcinoma
复制标题
头颈腺鳞癌：传统鳞状细胞癌的病例对照研究
作者：
M. Mehrad;K. Trinkaus;J. Lewis
腺鳞癌（AdSC）被认为是鳞状细胞癌（SCC）的一种罕见变体，被认为更具临床侵袭性。数据非常有限，文献中关于结局的病例匹配数据非常少。腺癌成分的数量是否影响结果也是未知的。对23例AdSC和1137例SCC对照进行了回顾性病例对照研究。病例按解剖学亚部位、治疗方法匹配，口咽部按p16状态匹配。在分析中调整了以下变量：T分类（T1/T2 vs. T3/T4）、N分类（N 0-N2 a vs. N2 b-N3）、年龄和吸烟。腺癌成分通过包含低、中或高腺体的高倍视野的数量来量化。AdSCs具有显著更大的疾病复发风险，但在很大程度上，差异没有统计学意义。腺癌的数量与疾病复发或生存无关。这项关于AdSC的病例对照研究显示，即使在控制口咽病例的p16状态时，AdSC的临床侵袭性行为也比传统SCC适度。此外，它表明目前对AdSC的定义，没有对腺体形成的最低要求，在临床上是准确的。
Adenosquamous carcinoma (AdSC) is considered a rare variant of squamous cell carcinoma (SCC) which is considered to be more clinically aggressive. Data is very limited with very little case matched data on outcomes in the literature. It is also unknown whether the quantity of the adenocarcinoma component affects outcomes. A retrospective case–control study with 23 cases of AdSC and 1137 SCC controls was conducted. Cases were matched by anatomic subsite, treatment, and, for oropharynx, by p16 status. The following variables were adjusted for in the analysis: T classification (T1/T2 vs. T3/T4), N classification (N0–N2a vs. N2b–N3), age, and smoking. The adenocarcinoma component was quantified by the number of high power fields containing glands as low, moderate, or high. AdSCs had a significantly greater risk of disease recurrence but largely, the differences were not statistically significant. The quantity of adenocarcinoma did not correlate with disease recurrence or survival. This case–control study on AdSC shows modestly more clinically aggressive behavior than conventional SCC, even while controlling for p16 status for oropharyngeal cases. Further, it suggests the current definition of AdSC, with no minimum requirement for gland formation, is clinically accurate.
DOI：
10.1056/nejmoa0912217
发表时间：
2010-07-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ang KK;Harris J;Wheeler R;Weber R;Rosenthal DI;Nguyen-Tân PF;Westra WH;Chung CH;Jordan RC;Lu C;Kim H;Axelrod R;Silverman CC;Redmond KP;Gillison ML
通讯作者：
Gillison ML
早期口腔舌鳞状细胞癌：从肿瘤床边缘取样和较差的局部控制。
DOI：
10.1001/jamaoto.2015.1351
发表时间：
2015-12
期刊：
JAMA otolaryngology-- head & neck surgery
影响因子：
--
作者：
Maxwell JH;Thompson LD;Brandwein-Gensler MS;Weiss BG;Canis M;Purgina B;Prabhu AV;Lai C;Shuai Y;Carroll WR;Morlandt A;Duvvuri U;Kim S;Johnson JT;Ferris RL;Seethala R;Chiosea SI
通讯作者：
Chiosea SI